This Study Utilized Fermented Lingonberry Juice in a Spray Form, Allowing it to be Applied to the Mouth Four Times a Day.

NCT07143344 | Completed DMC

• 5 other identifiers: LING_TRETYH2022225TYH 2024332TYH 2025382Y2519SU010
• Study Type: interventional
• Target: 11
• Locations: 1 country
• Sites: 1

Brief Summary

A human intervention study was performed to examine the antimicrobial effects of fermented lingonberry spray (FLJ spray) treatment, used for a period of 30 days.

Conditions

Bleeding on Probing; Pocket Depth; Plaque Control; Saliva Microbiome

Keywords

fermented lingonberry juice; saliva test; mouthrinse; aMMP-8 test

Outcome Measures

Primary Outcomes (2)

• The effects of fermented lingonberry spray in the mouth.

  Changes of bleeding on probing (BOP), from six measurement point, visible plaque index (VPI), score 1-3, probing pocket depths (PPD) and active-matrix metalloproteinase - 8 (aMMP-8) mouthrinse assays (Cutt-off 20 ng/ml), numerical value were carried out to one month.

  Up to one month

• the time points on the levels of each salivary parameter were determined with the repeated measures ANOVA analysis.

  6 weeks

Study Arms (1)

Adult patients were randomly selected from a private dental clinic in Tampere, Finland for the study

EXPERIMENTAL

Participants used approximately ten sprays four times a day (approx. 5,5 ml/ day) of FLJ-spray (Lingora® Oral Spray, Berries United Ltd, Helsinki, Finland) for a month.

Other: Fermented lingonberry juice sprey

Interventions

Fermented lingonberry juice sprey OTHER

Patented fermented lingonberry juice sprey

Also known as: FLJ, fermented lingonberry juice

Adult patients were randomly selected from a private dental clinic in Tampere, Finland for the study

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy patients or patients with systemic diseases with good cognitive abilities
• with or without xerostomia.

You may not qualify if:

• use of other mouthwash products, including chlorhexidine
• current use of antibiotics.

Sponsors & Collaborators

• Lahanna oy: lead
• University of Helsinki: collaborator

Study Sites (1)

University of Helsinki

Tampere, 33100, Finland

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 12, 2025
• First Posted: August 27, 2025
• Study Start: March 1, 2025
• Primary Completion: June 30, 2025
• Study Completion: July 30, 2025
• Last Updated: August 27, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, CSR

Locations

FI (1)