NCT07143110

Brief Summary

LUNG-ROLL is a retrospective cohort study that will describe the contemporary treatment patterns, prevalence and incidence, patient demographic and clinical characteristics, clinical outcomes, and healthcare resource use/costs for patients with lung cancer in Canada (specifically, Alberta and Ontario) using administrative data.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60,000

participants targeted

Target at P75+ for all trials

Timeline
17mo left

Started Aug 2025

Typical duration for all trials

Geographic Reach
1 country

2 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress34%
Aug 2025Sep 2027

First Submitted

Initial submission to the registry

May 30, 2025

Completed
3 months until next milestone

Study Start

First participant enrolled

August 20, 2025

Completed
7 days until next milestone

First Posted

Study publicly available on registry

August 27, 2025

Completed
2.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 30, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 30, 2027

Last Updated

March 2, 2026

Status Verified

February 1, 2026

Enrollment Period

2.1 years

First QC Date

May 30, 2025

Last Update Submit

February 26, 2026

Conditions

Keywords

Lung NeoplasmsNon-Small-Cell LungSmall Cell LungEpidemiologyTreatment PatternsReal-World

Outcome Measures

Primary Outcomes (1)

  • Treatment patterns

    Through study completion, an average of 1 year

Secondary Outcomes (7)

  • Incidence and prevalence

    Through study completion, an average of 1 year

  • Baseline demographic and clinical characteristics

    Through study completion, an average of 1 year

  • Overall survival

    Through study completion, an average of 6 months

  • Time to/on therapy

    Through study completion, an average of 6 months

  • Attrition rates

    Through study completion, an average of 1 year

  • +2 more secondary outcomes

Study Arms (2)

Non-Small Cell Lung Cancer (NSCLC)

Small Cell Lung Cancer (SCLC)

Eligibility Criteria

Age18 Years - 130 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Study population will comprise patients with lung cancer diagnosed after January 1, 2018 in the administrative databases for Alberta and Ontario.

You may qualify if:

  • Patients with lung cancer between January 1, 2018 and end of the Selection Period.
  • Patient is 18 years of age or older on diagnosis date.
  • Patient has at least 12 months of health insurance coverage prior to the diagnosis date.

You may not qualify if:

  • Diagnosed with any other cancer in the 5-year period prior to January 1, 2018.
  • Diagnosed with any other cancer concurrently (i.e., on the same date) as lung cancer diagnosis.
  • Invalid or incomplete records for key variables (e.g., missing year of diagnosis, missing cancer type).
  • Non-Ontario or non-Alberta resident on diagnosis date.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Research Site

Calgary, Alberta, T2N1N4, Canada

RECRUITING

Research Site

Toronto, Ontario, M5T3M6, Canada

RECRUITING

MeSH Terms

Conditions

Lung Neoplasms

Condition Hierarchy (Ancestors)

Respiratory Tract NeoplasmsThoracic NeoplasmsNeoplasms by SiteNeoplasmsLung DiseasesRespiratory Tract Diseases

Central Study Contacts

AstraZeneca Clinical Study Information Center

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 30, 2025

First Posted

August 27, 2025

Study Start

August 20, 2025

Primary Completion (Estimated)

September 30, 2027

Study Completion (Estimated)

September 30, 2027

Last Updated

March 2, 2026

Record last verified: 2026-02

Data Sharing

IPD Sharing
Will not share

Locations