Effect of Acute Grape Seed Extract Supplementation on the Heart Rate Recovery in Young Individuals

NCT07137988 | Completed

• 1 other identifier: 034-2425-EXP
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

This study hypothesized that sustained sympathoexcitation via MMA slows down PHRR and that GSE supplementation is effective at improving PHRR in young individuals. 12 Participants were randomly assigned, via a double-blind, cross-over design, to either receive GSE (300mg, 2 capsules) or PL (300mg, 2 capsules), with a washout period of at least 72 hrs. between trials. A submaximal exercise test was performed using a cycle ergometer combined with isometric handgrip exercise using a handgrip dynamometer, and blood flow occlusion by placing a cuff over the brachial artery of the dominant arm. Post heart rate recovery (PHRR) was measured at 5 sec. intervals throughout the experiment. The PHRR was evaluated between GSE and PL at every min. for 300 sec.

Conditions

Healthy Young Men

Keywords

Double blinded cross-over design

Outcome Measures

Primary Outcomes (1)

• Heart rate recovery every minute and heart rate kinetics (tau) following exercise

  5 min after exercise

Study Arms (2)

Experimental: Heart rate recovery with grape seed extract

EXPERIMENTAL

Grape seed extract: 300 mg, two capsules Starch: 300 mg, two capsules

Dietary Supplement: 600 mg grape seed extract; Dietary Supplement: 600 mg Starch

Sham Comparator: Experimental: BFR exercise without histamine blockade

PLACEBO COMPARATOR

Heart rate recovery with placebo (starch, 300 mg, 2 capsules)

Dietary Supplement: 600 mg grape seed extract; Dietary Supplement: 600 mg Starch

Interventions

600 mg grape seed extract DIETARY_SUPPLEMENT

Each participant took either GSE (300 mg, 2 capsules) or a placebo (300 mg, 2 capsules filled with starch) 2 hours before their scheduled lab visit. The supplements were made to look identical to prevent any bias from the participants or the testers. There was a washout period of at least 72 hours, but no more than a week, between each trial.

Also known as: 600 mg starch

Experimental: Heart rate recovery with grape seed extract; Sham Comparator: Experimental: BFR exercise without histamine blockade

600 mg Starch DIETARY_SUPPLEMENT

Each participant took either GSE (300 mg, 2 capsules) or a placebo (300 mg, 2 capsules filled with starch) 2 hours before their scheduled lab visit. The supplements were made to look identical to prevent any bias from the participants or the testers. There was a washout period of at least 72 hours, but no more than a week, between each trial.

Experimental: Heart rate recovery with grape seed extract; Sham Comparator: Experimental: BFR exercise without histamine blockade

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• good health, nonsmokers, those not taking medications that could affect cardiovascular function

You may not qualify if:

• hypertension, muscular skeletal disorders

Sponsors & Collaborators

• California Baptist University: lead

Study Sites (1)

California Baptist University

Riverside, California, 92504, United States

Location

MeSH Terms

Interventions

Grape Seed Extract; Starch

Intervention Hierarchy (Ancestors)

Plant Extracts; Plant Preparations; Biological Products; Complex Mixtures; Pharmaceutical Preparations; Glucans; Biopolymers; Polymers; Macromolecular Substances; Dietary Carbohydrates; Carbohydrates; Polysaccharides

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: August 15, 2025
• First Posted: August 22, 2025
• Study Start: October 3, 2024
• Primary Completion: December 3, 2024
• Study Completion: December 31, 2024
• Last Updated: August 22, 2025

Record last verified: 2025-08

Locations

US (1)