Electrocardiographic Changes Associated With Epilepsy
1 other identifier
observational
80
0 countries
N/A
Brief Summary
Identify and characterize electrocardiographic (ECG) changes occurring during the post-ictal phase of epileptic seizures. Evaluate the duration and severity of post-ictal ECG abnormalities. Assess the correlation between ECG changes and seizure type, duration, and severity. Explore the association of ECG changes with patient demographics
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Oct 2025
Shorter than P25 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 18, 2025
CompletedFirst Posted
Study publicly available on registry
August 22, 2025
CompletedStudy Start
First participant enrolled
October 1, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
October 1, 2026
August 22, 2025
August 1, 2025
11 months
July 18, 2025
August 20, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Out come measure
Title: Prevalence of Post-Ictal Electrocardiographic (ECG) Abnormalities Description: The proportion of participants who experience post-ictal ECG abnormalities, including sinus tachycardia, bradycardia, QT/QTc interval changes, ST-T segment changes, atrial/ventricular ectopy, or conduction blocks. Assessment will be performed using a standard 12-lead electrocardiogram (ECG). Unit of Measure: Percentage of participants
Baseline (immediate post-ictal phase)
Eligibility Criteria
Eighty (80) children with epilepsy will be included in this study during the period from October 2025 to October 2026. Sample size was calculated by Open Epi Info version 3
You may qualify if:
- Children from 1 year to 18 year are diagnosed with epilepsy.
- Routine EEG.
You may not qualify if:
- Known pre-existing cardiac conditions e.g arrhythmias, heart failure.
- Current use of medications significantly affecting ECG.
- Other causes of convulsion:hypoglycemia,hypernatriemia.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (3)
Katyayan A, Diaz-Medina G. Epilepsy: Epileptic Syndromes and Treatment. Neurol Clin. 2021 Aug;39(3):779-795. doi: 10.1016/j.ncl.2021.04.002.
PMID: 34215386BACKGROUNDIbrahim A, Megahed A, Salem A, Zekry O. Impact of Cardiac Injury on the Clinical Outcome of Children with Convulsive Status Epilepticus. Children (Basel). 2022 Jan 18;9(2):122. doi: 10.3390/children9020122.
PMID: 35204843BACKGROUNDBastos F, Cross JH. Epilepsy. Handb Clin Neurol. 2020;174:137-158. doi: 10.1016/B978-0-444-64148-9.00011-9.
PMID: 32977874BACKGROUND
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Resident Doctor, Department of Pediatrics, Assiut University Children's Hospital
Study Record Dates
First Submitted
July 18, 2025
First Posted
August 22, 2025
Study Start
October 1, 2025
Primary Completion (Estimated)
September 1, 2026
Study Completion (Estimated)
October 1, 2026
Last Updated
August 22, 2025
Record last verified: 2025-08