NCT07133503

Brief Summary

According to the literature age and gender may be associated with differences in skeletal size, anatomy and architecture in humans. However, little is known about the synergistic effects of age and gender on the healing capacity of maxillary bones, since most of the preclinical studies are focused on each variable separately. The present study radiologically evaluated various parameters such as alveolar crest height and width, buccal bone thickness, degree of buccal undercut, and root-crest angle using cone-beam computed tomography (CBCT) in a large patient population, and compared these parameters across different age and gender groups to analyze the effect of aging and gender on the bone morphology in the anterior maxillary region.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
278

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2024

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2024

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2025

Completed
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2025

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

July 22, 2025

Completed
1 month until next milestone

First Posted

Study publicly available on registry

August 21, 2025

Completed
Last Updated

August 21, 2025

Status Verified

August 1, 2025

Enrollment Period

1 year

First QC Date

July 22, 2025

Last Update Submit

August 18, 2025

Conditions

Keywords

Immediate implant applicationsCone-beam computed tomographyAnterior maxillaAlveolar ridge morphologyAging

Outcome Measures

Primary Outcomes (5)

  • Alveolar Crest Height

    The height of the alveolar crest was defined as the length of a line drawn parallel to the crest's long axis between the nasal fossa floor and the alveolar crest.

    One year

  • Alveolar Crest Width

    The width of the alveolar crest was calculated by averaging measurements taken from the midpoints of three equal sections of the alveolar crest.

    One year

  • Buccal Bone Thickness

    To determine buccal bone thickness, measurements were taken from the buccal crest apex, the midpoint of the root, and the apex of the tooth.

    One year

  • Buccal Undercut Depth

    The buccal undercut was determined as the point where the crest came closest to the root in the sagittal plane.

    One year

  • Root Position

    the angle between the tooth roots and the alveolar crest was measured to determine the root position in the radial plane

    One year

Study Arms (6)

20-29 age group

In this age group bilateral central incisors, lateral incisors, and canines in the upper anterior region were examined

Other: radiological evaluation

30-39 age group

In this age group bilateral central incisors, lateral incisors, and canines in the upper anterior region were examined

Other: radiological evaluation

40-49 age group

In this age group bilateral central incisors, lateral incisors, and canines in the upper anterior region were examined

Other: radiological evaluation

50-59 age group

In this age group bilateral central incisors, lateral incisors, and canines in the upper anterior region were examined

Other: radiological evaluation

60-69 age group

In this age group bilateral central incisors, lateral incisors, and canines in the upper anterior region were examined

Other: radiological evaluation

70-80 age group

In this age group bilateral central incisors, lateral incisors, and canines in the upper anterior region were examined

Other: radiological evaluation

Interventions

Using a line drawn through the midpoints of the teeth, parallel to their long axes, the anterior crest morphology was assessed. For maxillary central, lateral, and canine teeth, alveolar crest width and height, buccal bone thickness, and tooth-crest angle were measured separately. To determine buccal bone thickness, measurements were taken from the buccal crest apex, the midpoint of the root, and the apex of the tooth. The height of the alveolar crest was defined as the length of a line drawn parallel to the crest's long axis between the nasal fossa floor and the alveolar crest. The width of the alveolar crest was calculated by averaging measurements taken from the midpoints of three equal sections of the alveolar crest. The buccal undercut was determined as the point where the crest came closest to the root in the sagittal plane. Additionally, the angle between the tooth roots and the alveolar crest was measured to determine the root position in the radial plane

20-29 age group30-39 age group40-49 age group50-59 age group60-69 age group70-80 age group

Eligibility Criteria

Age20 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Cone-beam coemputed tomography (CBCT) images of individuals, obtained for various diagnostic purposes at the Erciyes University Faculty of Dentistry, Oral and Maxillofacial Radiology Clinic between January 2015 and January 2024

You may qualify if:

  • Between January 2015 and January 2024, undergoing CBCT imaging at the Erciyes University Faculty of Dentistry, Department of Oral and Maxillofacial Radiology

You may not qualify if:

  • Systemic diseases,
  • Anterior maxillary tooth loss,
  • Having root canal treatments,
  • Periapical lesions,
  • History of or ongoing periodontal disease,
  • Smoking.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Erciyes University Faculty of Dentistry Department of Periodontology

Kayseri, Kayseri̇, 38000, Turkey (Türkiye)

Location

Erciyes University

Kayseri, Melikgazi, 38000, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Retrognathia

Condition Hierarchy (Ancestors)

Jaw AbnormalitiesJaw DiseasesMusculoskeletal DiseasesMaxillofacial AbnormalitiesCraniofacial AbnormalitiesMusculoskeletal AbnormalitiesStomatognathic DiseasesMandibular DiseasesStomatognathic System AbnormalitiesCongenital AbnormalitiesCongenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

  • Duygu Kilic

    TC Erciyes University

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant professor

Study Record Dates

First Submitted

July 22, 2025

First Posted

August 21, 2025

Study Start

January 1, 2024

Primary Completion

January 1, 2025

Study Completion

May 1, 2025

Last Updated

August 21, 2025

Record last verified: 2025-08

Data Sharing

IPD Sharing
Will not share

Locations