Study of Efficacy and Safety of Cream Infused With HuangQin (Root of Scutellaria Baicalensis) Extract for the Reduction of Hyperpigmentation

NCT07133204 | Completed

• 1 other identifier: EC 24061-25
• Study Type: interventional
• Target: 38
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to evaluate the efficacy of a topical cream infused with Scutellaria baicalensis extract in reducing hyperpigmentation on the face. The study is experimental clinical pilot study as a single group pretest-posttest. A ROAT is conducted 1 week prior to the experiment. Participant apply the cream on the hypigmented area daily. Facial skin parameters (i.e. melanin index, erythema index) is evaluated at week 0, 1, 2 and 4.

Conditions

Hyperpigmentation; Melanin

Keywords

hyperpigmentation, scutellaria baicalensis, melanin index

Outcome Measures

Primary Outcomes (2)

• Efficacy of hyperpigmentation reduction property of the intervention

  Measured the melanin index of the hyperpigmented area

  Week 0, 1, 2 and 4

• Safefty profile of the intervention

  Record and collect the adverse effect from the usage of the interventional cream

  Week 1, 2 and 4

Secondary Outcomes (2)

• Efficacy of erythema reduction property of the intervention

  Week 0, 1, 2 and 4

• Efficacy of skin hydration property of the intervention

  Week 0, 1, 2 and 4

Study Arms (1)

Study arm

EXPERIMENTAL

Other: Investigator developed cream infused with HuangQin extract

Interventions

Investigator developed cream infused with HuangQin extract OTHER

A water in oil emulsion with consistency similar to cold cream. Infused with organic extract of scutellaria baicalensis.

Study arm

Eligibility Criteria

• Age: 30 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male or Female
• Has at least 1 hyperpigmentation spot (size \> 3mm) on either side of the face
• y/o
• Fitzpatrick skin types II-IV
• Agrees to use sunscreen SPF50+ and willing to avoid strong sunlight exposure during the study

You may not qualify if:

• Pregnant or lactating
• Use of whitening products or treatment within 1 month before this study
• Currently using contraceptives
• History of allergy to any ingredient in the intervention cream
• Has skin conditions which can interfere with the measurement (i.e. severe acne, eczema, herpes simplex)
• Severe disease (i.e. immunodeficiency, cancer)
• Enrolled in other clinical study within 3 month before this study

Sponsors & Collaborators

• Mae Fah Luang University: lead

Study Sites (1)

Mae Fah Luang University

Muang, Changwat Chiang Rai, 57100, Thailand

Location

MeSH Terms

Conditions

Hyperpigmentation

Interventions

Scutellaria baicalensis extract

Condition Hierarchy (Ancestors)

Pigmentation Disorders; Skin Diseases; Skin and Connective Tissue Diseases

Study Officials

• Chakree C Wattanasiri, RPh PhD

  Mae Fah Luang University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 13, 2025
• First Posted: August 20, 2025
• Study Start: April 1, 2025
• Primary Completion: June 30, 2025
• Study Completion: July 20, 2025
• Last Updated: August 20, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

TH (1)