NCT07132918|SuspendedPhase 2DMCFDA Device
Study Stopped
Funding issues
HEARTS Trial for Thoracic Cancers
The cARdiac Radiation Therapy Sparing (HEARTS) for Thoracic Cancers
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Funding issues
The cARdiac Radiation Therapy Sparing (HEARTS) for Thoracic Cancers
Sponsor study identifier
Secondary identifiers
OTHER · UW Madison
OTHER · UW Madison
OTHER · UW Madison
interventional
60
1 country
1
Study Start
October 8, 2025
Actual (reported)Primary Completion
March 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
March 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The goal of this clinical trial is to compare a new way of using magnetic resonance-guided adaptive radiation therapy (MRgART) to the standard of care linear accelerator (LINAC) radiation treatment in people with cancer in the thoracic region near the heart. The main question it aims to answer is whether MRgART affects the heart differently than LINAC. Participants will:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 12, 2025
Actual (reported)August 20, 2025
Actual (reported)October 8, 2025
Actual (reported)March 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
March 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Change in left ventricular ejection fraction (LVEF)
Changes are measured between timepoints as determined by cardiac MRI. LVEF is calculated by dividing the left ventricular (LV) stroke volume (the amount of blood pumped out) by the end-diastolic volume (the amount of blood in the left ventricle before contraction) and multiplying by 100.
Pre-treatment, 3 months post-treatment, 6 months post-treatment
Change in right ventricular function (RVEF)
Pre-treatment, 3 months, 6 months post-treatment
Change in left and right ventricular (LV/RV) volumes
Pre-treatment, 3 months, 6 months post-treatment
Participants randomized to this arm will receive magnetic resonance-guided adaptive radiation therapy (MRgART)
Participants randomized to this arm will receive linear accelerator (LINAC) radiation therapy
Magnetic Resonance-guided Adaptive Radiation Therapy (MRgART) is a form of MRgRT that incorporates daily adaptive planning, or making a new treatment plan each treatment, and real-time imaging during treatment delivery.
Daily 3D x-ray scans will be obtained for radiation delivery to confirm tumor and organ at risk placement.
University of Wisconsin - Madison
Madison, Wisconsin, 53705, United States
Carri Glide-Hurst, PhD, DABR, FAAPM
University of Wisconsin, Madison
First Submitted
August 12, 2025
First Posted
August 20, 2025
Study Start
October 8, 2025
Actual (reported)Primary Completion
March 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Change in myocardial strain
Pre-treatment, 3 months, 6 months post-treatment
Change in T1 Mapping
Pre-treatment, 3 months, 6 months post-treatment
Change in extracellular volume fraction (ECV)
Pre-treatment, 3 months, 6 months post-treatment
Contact the study team to confirm eligibility.
Study Completion
March 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 30, 2026
Record last verified: 2026-09
De-identified individual participant data (IPD) collected during the study will be shared in accordance with the NIH Data Management and Sharing Policy. Data will be made available to qualified researchers for the purpose of secondary analyses that are consistent with the informed consent provided by participants. The data will be de-identified to protect participant privacy and confidentiality.
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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