Physical Therapy After Endometriosis Excision

NCT07127783 | Recruiting

• 1 other identifier: STUDY00028168
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This is a randomized controlled pilot study comparing a home pelvic floor physical therapy program to routine post-operative care for patients undergoing endometriosis excisional surgery without hysterectomy. Quality of life and endometriosis symptoms will be compared following the recovery period.

Conditions

Endometriosis; Surgery

Keywords

Active Recovery

Outcome Measures

Primary Outcomes (2)

• Short Form Survey (SF-36)

  The Short Form Survey (SF-36) is a 36-item survey regarding general health and pain and its impact on quality of life including physical activities, work, social activities, and emotional well-being over the last four weeks. Scores range from 0 to 100 with a higher score representing a more favorable health state.

  Collected immediately following surgery, 6 weeks following surgery, and 12 weeks following surgery

• Pelvic Floor Impact Questionnaire (PFIQ)

  The Pelvic Floor Impact Questionnaire (PFIQ) asks about how bladder, bowel, and pelvic symptoms affect the ability to do physical activities as well as their impact on emotional well-being over the last 3 months. Scores range from 0 to 300 with a lower score representing a lesser impact on quality of life.

  Collected immediately following surgery and 12 weeks following surgery

Secondary Outcomes (2)

• Pain Scores

  Collected at baseline, 6 weeks following surgery, and 12 weeks following surgery.

• Endometriosis Health Profile (EHP-5)

  Collected at baseline, 6 weeks following surgery, and 12 weeks following surgery.

Study Arms (2)

Standard Postoperative Instructions

ACTIVE COMPARATOR

Participants will receive standard postoperative recovery instructions

Behavioral: Standard Postoperative Instructions

Active Recovery

EXPERIMENTAL

Participants will receive postoperative instructions to follow an active recovery protocol focused on increasing activity level, core strength exercises, and pelvic floor exercises focused on urinary and bowel symptoms. Exercises are to be completed twice per day for the 12 weeks following surgery.

Behavioral: Active Recovery

Interventions

Active Recovery BEHAVIORAL

Participants will receive postoperative instructions to follow an active recovery protocol focused on increasing activity level, core strength exercises, and pelvic floor exercises focused on urinary and bowel symptoms. Exercises are to be completed twice per day for the 12 weeks following surgery.

Active Recovery

Standard Postoperative Instructions BEHAVIORAL

Standard of care postoperative instructions covering incision care, pain control, dietary instructions, and emergency precautions. Also includes guidelines regarding pelvic rest and lifting restrictions.

Standard Postoperative Instructions

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Premenopausal
• English speaking
• Undergoing endometriosis excision surgery without hysterectomy at Legacy Health with subspecialty-trained surgeons specializing in endometriosis care
• History of chronic pelvic pain (defined as \>= 6 months of pain in the anatomic pelvis)
• Diagnosis of high tone pelvic floor dysfunction on examiniation
• Have access to reliable email and phone for study-related communication

You may not qualify if:

• Non-English speaking
• Unable to consent
• Unable to sustain 30 minutes of moderate activity at baseline
• Uses a mobility assistive device at baseline
• Chronic opioid use
• No histologic diagnosis of endometriosis on surgical pathology
• Need for additional pelvic rest (\>2 weeks) postoperatively
• Pregnancy or planning to pursue pregnancy or undergo fertility treatments within 12 weeks postoperatively

Sponsors & Collaborators

• Oregon Health and Science University: lead

Study Sites (1)

Oregon Health & Science University

Portland, Oregon, 97239, United States

RECRUITING

MeSH Terms

Conditions

Endometriosis

Condition Hierarchy (Ancestors)

Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases

Study Officials

• Jacqueline Wong

  Oregon Health and Science University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Women's Health Research Unit Department of Ob/Gyn

CONTACT

503-494-3666; whru@ohsu.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Participants will be randomized in a 1:1 ratio to either standard postoperative instructions or the active recovery intervention group.

Study Record Dates

• First Submitted: August 11, 2025
• First Posted: August 17, 2025
• Study Start: August 28, 2025
• Primary Completion: March 1, 2026
• Study Completion: March 1, 2026
• Last Updated: October 6, 2025

Record last verified: 2025-09

Locations

US (1)