Lotion and Toner Bundle 4-Week Lifting Efficacy Study

NCT07127653 | Completed

• 1 other identifier: C25005018
• Study Type: interventional
• Target: 132
• Locations: 1 country
• Sites: 1

Brief Summary

This is a single-center, parallel-arm, 4-week interventional study designed to evaluate the lifting and firming efficacy of two facial care regimens in middle-aged Chinese women. Participants were randomly assigned to use either a retinol-based day cream or a lotion-and-toner bundle. The study included dermatologist assessment, standardized facial photography, and self-assessment questionnaires. A total of 132 healthy women aged 45-55 with facial skin sagging were enrolled. The primary objective was to compare improvement in lifting grades after 4 weeks of product use. The trial was conducted at China-Norm Quality Technical Service Co., Ltd., in Shanghai, China.

Conditions

Lifting Efficacy; Facial Aging

Outcome Measures

Primary Outcomes (1)

• Clinical Assessment by Dermatologist

  Lifting grade (0-9 scale) will be evaluated by dermatologist at T-3w, T0 (baseline), Timm and T4w.Six areas will be evaluated separately: eyebrow, upper eyelid, nasolabial zone, apple cheek, corner of mouth and jaw.

  Baseline and Week 4

Secondary Outcomes (2)

• Change in Facial Wrinkle Depth Measured by Standardized Digital Photography and Image Analysis Software

  Baseline and Week 4

• Questionnaire

  Baseline and Week 4

Study Arms (2)

Retinol Day Cream Group

EXPERIMENTAL

Participants in this arm applied a retinol-based anti-wrinkle day cream to the full face for 4 weeks following a 3-week washout period. Assessments were conducted at baseline (T0), immediate post-use (Timm), and after 4 weeks of use (T4w). Evaluations included dermatologist lifting grade, DEEP imaging, and self-assessment questionnaire.

Other: Lotion and Toner Bundle

Lotion and Toner Group

EXPERIMENTAL

Participants in this arm applied a lotion and toner bundle to the full face for 4 weeks following a 3-week washout period. Assessments were conducted at baseline (T0), immediate post-use (Timm), and after 4 weeks of use (T4w). Evaluations included dermatologist lifting grade, DEEP imaging, and self-assessment questionnaire.

Other: Retinol-Based Day Cream

Interventions

Retinol-Based Day Cream OTHER

A commercially available day cream containing retinol and moisturizing ingredients. Applied twice daily (morning and evening) to the full face for 4 weeks.

Lotion and Toner Group

Lotion and Toner Bundle OTHER

A skincare regimen including a dermalift toner and a milky lotion. Applied twice daily (morning and evening) to the full face for 4 weeks.

Retinol Day Cream Group

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• \. Chinese female with 45-55 years old. 2. All skin types (dry, normal, oily or mixed). 3. Regular users for toner, lotion and cream. 4. Self-claim with lack of firmness and has sagging concern. 5. Presenting with corresponding severity for the attribute evaluated by Dermatologist included:
• Lifting (global face): 3≤grade≤6 (0-9 scale) 6. The BMI range should ≤24.9, and the BMI (BMI =Weight (kg)/ Height²(m²)) should remain stable within the range throughout the entire testing period. 7. Did not participate any clinical test or cosmetic product test on skin within 3 months.
• \. Did not participate any chemical procedures for previous 6 months and during the whole study.
• \. No disagreement of dermatologist because of other reasons that exclude the participation of the subject.
• \. In general, good health at the time of the study. 11. Willing and able to participate as evidenced by signing of informed consent \& photo release form.
• \. Must be willing to comply with all study protocol requirements (pay attention: only use the skin care products provided during the study, not take topical or oral treatment like retinol, hormone, antioxidant health-care products which may affect the test product).

You may not qualify if:

• \. Pregnant or breast-feeding woman or woman planning pregnancy during the study.
• \. Subject deprived of rights by a court or administrative order. 3. Major subject to a guardianship order. 4. Subject residing in a health or social care establishment. 5. Patient in an emergency setting. 6. Subject with a skin disease in the test areas as well as skin allergy (particularly e.g., acne, rosacea, eczema). 7. Subject presenting a stable or progressive serious disease (per investigator's assessment).
• \. Immuno-compromised subject. 9. Subject with history of allergy to cosmetic or personal care products or ingredients.
• \. Subject presenting excessive exposure to sunlight or UV radiation (investigator's assessment).
• \. Subject with history of sunlight sensitivity or allergies. 12. Subjects regularly practicing aquatic or nautical sports. 13. Subjects regularly attending a sauna. 14. Subject with physical highly sensitive constitution. 15. Subject with cardiovascular or circulatory history. 16. Subject with a history of skin cancer or malignant melanoma. 17. Intake of antihistamines, antibiotics, corticosteroids, non-steroidal anti-inflammatories or immune suppressants in the last 6 months before study

Sponsors & Collaborators

• ChinaNorm: lead

Study Sites (1)

Shanghai China-norm Quality Technical Service Co., Ltd., Shanghai, Shanghai 200072

Shanghai, China

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 1, 2025
• First Posted: August 17, 2025
• Study Start: January 23, 2025
• Primary Completion: March 16, 2025
• Study Completion: March 31, 2025
• Last Updated: August 17, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)