NCT07127263

Brief Summary

Between 2010-2020, the LungCAst observational study followed 3700 patients newly diagnosed with lung cancer across 33 hospitals in Wales and England for 2 years to see if smoking status at time of diagnosis predicted survival rate. This research was sponsored and led by Hywel Dda University Health Board (HDUHB). This new study examines the health records, (of only the HDUHB participants included in the original LungCAst study), over a longer period of time to see if the benefits of stopping smoking at point of diagnosis with lung cancer continues over a longer period of time (5 years+).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
525

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Sep 2024

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 5, 2024

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 4, 2025

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

May 7, 2025

Completed
23 days until next milestone

Study Completion

Last participant's last visit for all outcomes

May 30, 2025

Completed
3 months until next milestone

First Posted

Study publicly available on registry

August 17, 2025

Completed
Last Updated

August 17, 2025

Status Verified

April 1, 2025

Enrollment Period

5 months

First QC Date

May 7, 2025

Last Update Submit

August 11, 2025

Conditions

Lung Cancer - Non Small Cell Squamous

Keywords

Smoking cessationLung cancerSurvivalTobacco

Outcome Measures

Primary Outcomes (1)

  • Comparison of longer-term (5 year+) outcomes (survival) of smokers, ex-smokers and never smokers diagnosed with lung cancer between 2010 and 2020

    Following participants with lung cancer over a 5 year period, by reviewing ongoing healthcare activity via HES extraction and applying the Kaplan-Meier method, to evaluate if smoking status at diagnosis predicts better survival rates over a longer period of time. Univariate and multivariate analysis on the effect of smoking status on survival will also be applied.

    From date of diagnosis (of having lung cancer) for 5 years

Study Arms (1)

Diagnosed Lung Cancer

Patients diagnosed with Lung Cancer, with smoking status recorded at time of diagnosis.

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients from the Hywel Dda University Health Board's (HDUHB) site that participated in the original LungCast study.

You may qualify if:

  • All patients from the Hywel Dda University Health Board's(HDUHB) site that participated in the original LungCast study

You may not qualify if:

  • Individuals that did not participate in the original LungCast study in the HDUHB site.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hywel Dda University Health Board

Carmarthen, Carmarthenshire, SA31 3BB, United Kingdom

Location

MeSH Terms

Conditions

Smoking CessationLung Neoplasms

Condition Hierarchy (Ancestors)

Health BehaviorBehaviorRespiratory Tract NeoplasmsThoracic NeoplasmsNeoplasms by SiteNeoplasmsLung DiseasesRespiratory Tract Diseases

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 7, 2025

First Posted

August 17, 2025

Study Start

September 5, 2024

Primary Completion

February 4, 2025

Study Completion

May 30, 2025

Last Updated

August 17, 2025

Record last verified: 2025-04

Locations

GB(1)