Thermal Radiofrequency Neurolysis Versus Alcoholic Neurolysis of the Genicular Nerves for Treatment of Chronic Knee Pain in Advanced Knee Osteoarthritis

NCT07125768 | Completed

• 1 other identifier: 36264MS603/5/24
• Study Type: interventional
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to compare the strength and duration of pain relief, quality of life and analgesic consumption between patients who undergo conventional thermal radiofrequency vs patients who undergo chemical neurolysis on genicular nerves by alcohol in chronic knee osteoarthritis pain.

Conditions

Thermal Radiofrequency Neurolysis; Alcoholic Neurolysis; Genicular Nerves; Treatment; Chronic Knee Pain; Advanced Knee Osteoarthritis

Outcome Measures

Primary Outcomes (1)

• Improvement of knee osteoarthritis pain

  Improvement of knee osteoarthritis pain according to Visual Analogue Scale (VAS). VAS: which was a subjective scale used to quantitatively assess pain (0 = No pain, 10 = Severe pain).

  6 months post-procedure

Secondary Outcomes (2)

• Improvement of quality of life

  6 months post-procedure

• Decrease of analgesic requirements of pain control after neurolysis.

  6 months post-procedure

Study Arms (2)

Group I

EXPERIMENTAL

Patients received C-arm guided neurolysis of superior medial \[SM\], superior lateral \[SL\], and inferior medial \[IM\] genicular nerves by thermal radiofrequency.

Other: Thermal Radiofrequency Neurolysis

Group II

ACTIVE COMPARATOR

Patients received C-arm guided injection of each of the three genicular nerves with 1 ml of a solution containing 70% alcohol in 0.25% lidocaine.

Other: Alcoholic Neurolysis

Interventions

Thermal Radiofrequency Neurolysis OTHER

Patients received C-arm guided neurolysis of superior medial \[SM\], superior lateral \[SL\], and inferior medial \[IM\] genicular nerves by thermal radiofrequency.

Group I

Alcoholic Neurolysis OTHER

Patients received C-arm guided injection of each of the three genicular nerves with 1 ml of a solution containing 70% alcohol in 0.25% lidocaine.

Group II

Eligibility Criteria

• Age: 40 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age from 40 to 60 years.
• Both sexes.
• Stage 3 and 4 knee osteoarthritis in patients who aren't responding to pharmacological treatment and aren't good candidates for knee replacement surgery.

You may not qualify if:

• Neurological disorders (Previous cerebrovascular stroke, neuropathy, or weakness).
• Bleeding disorders.
• Infection at or near the injection site.
• Presence of a pacemaker or defibrillator.
• Acute knee injury.
• Unstable knee joint.

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University

Tanta, El-Gharbia, 31527, Egypt

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident of Anesthesiology, Surgical Intensive Care and Pain Management Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Study Record Dates

• First Submitted: August 10, 2025
• First Posted: August 15, 2025
• Study Start: July 1, 2024
• Primary Completion: July 1, 2025
• Study Completion: July 1, 2025
• Last Updated: August 15, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of the study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)