Predictive Factors for Initial MMSE Score and Rapid Decline in Alzheimer's Disease Patients

NCT07122856 | Not Yet Recruiting

• 1 other identifier: 0114_NEUROLOGIE_TARGET MMSE
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This study looks at people with Alzheimer's disease to find out which factors are linked to their initial score on the Mini-Mental State Examination (MMSE) and which factors may predict a fast decline in their score over 12 months. Researchers will review medical records from patients seen at the Memory Clinic of Gonesse Hospital and analyze information such as age, education, medical history, nutrition, mood, and caregiver burden. The goal is to better understand what influences early cognitive performance and how quickly it changes, to help improve patient care and planning.

Conditions

Alzheimer Disease; Mini-Mental State Examination; Cognitive Dysfunction; Neuropsychological Tests; Caregivers

Outcome Measures

Primary Outcomes (1)

• Change in MMSE Score Over 12 Months - measured as either a decrease of ≥3 points on the Mini-Mental State Examination [MeSH] or patient institutionalization within 12 months.

  12 months

Eligibility Criteria

• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of all patients who attended the Memory Clinic at CH Gonesse between July 2023 and July 2025. From this group, participants will be selected if they have a confirmed diagnosis of Alzheimer's disease (based on NIAA 2018 or IWG 2021 criteria) and have undergone at least two MMSE assessments spaced 12 months apart. Data will be extracted from medical records and registries within this hospital setting.

You may qualify if:

• Confirmed diagnosis of Alzheimer's disease according to NIAA 2018 or IWG 2021 criteria
• At least two MMSE evaluations spaced 12 months apart
• Follow-up at the Memory Clinic of CH Gonesse

You may not qualify if:

• Presence of other neurodegenerative diseases (e.g., Frontotemporal Dementia, Multiple System Atrophy, Vascular Dementia, LATE)
• Patient has moved out of the study area (outside the CH Gonesse territory)

Sponsors & Collaborators

• Centre Hospitalier de Gonesse: lead

Study Sites (1)

Centre Hospitalier de Gonesse

Gonesse, France, France

Location

MeSH Terms

Conditions

Alzheimer Disease; Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders; Cognition Disorders

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 8, 2025
• First Posted: August 14, 2025
• Study Start: September 15, 2025
• Primary Completion: March 15, 2026
• Study Completion: March 15, 2026
• Last Updated: August 14, 2025

Record last verified: 2025-08

Locations

FR (1)