Aging of the Vascular Wall

NCT07122427 | Recruiting

• 1 other identifier: IRBN502025/CHUSTE
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Demographic aging is predicted to be one of the most significant social changes of the 21st century. Aging is a slow, multifactorial process that progressively impacts the integrity of cells, tissues, and organs. This decline in function increases the risk of numerous diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases (CVD). CVD, the leading global cause of death, becomes more prevalent with age. Aging contributes to endothelial dysfunction, vessel stiffness, thickening, and impaired platelet function. These changes disrupt hemostatic processes and increase the risk of cardiovascular complications. Despite preventive strategies CVD remain a major public health challenge. Cellular aging, or senescence, affects all cell types, particularly endothelial cells and platelets. However, little research has compared the aging rates of different blood vessel types, such as arteries and veins. Given their distinct compositions and developmental origins, it is likely that their aging processes differ at molecular, cellular, and physiological levels.

Conditions

Vascular Risk; Aging Disorder

Keywords

Cardiovascular diseases; Aging; Eendothelial dysfunction

Outcome Measures

Primary Outcomes (1)

• Biomarkers of ageing

  Detection of innovative biomarkers of ageing by microscope analysis.

  Day 1

Study Arms (3)

Youngs

Patients aged 18 to 30 requiring coronary artery bypass grafting (CABG).

Procedure: Graft collection

Middle-aged

Patients aged 30 to 60 requiring coronary artery bypass grafting (CABG).

Procedure: Graft collection

Elderly

Patients aged 60 and more requiring coronary artery bypass grafting (CABG).

Procedure: Graft collection

Interventions

Graft collection PROCEDURE

Sampling of superior venous and arterial grafts (internal mammary artery, great saphenous vein) after coronary artery bypass surgery.

Elderly; Middle-aged; Youngs

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients requiring coronary artery bypass grafting (CABG).

You may qualify if:

• Major patients requiring coronary artery bypass grafting (CABG).

You may not qualify if:

• Hypertension, diabetes, systemic inflammatory disease.

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Saint Etienne: lead

Study Sites (1)

CHU Saint-Etienne

Saint-Etienne, France, 42055, France

RECRUITING

MeSH Terms

Conditions

Cardiovascular Diseases

Study Officials

• Salvatore CAMPISI, MD

  CHU SAINT-ETIENNE

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Anne-Claire DUCHEZ, PhD

CONTACT

(0)477421423; anne-claire.duchez@efs.sante.fr

Salvatore CAMPISI, MD

CONTACT

(0)477829058; salvatore.campisi@chu-st-etienne.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 7, 2025
• First Posted: August 14, 2025
• Study Start: July 17, 2025
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: August 20, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)