Association Between Matrix Metalloproteinase-9 Gene Polymorphism and Susceptibility to Primary Open Angle Glaucoma Patients in Sohag University Hospital

NCT07119905 | Not Yet Recruiting

• 1 other identifier: Soh-Med--25-7-16MS
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to investigate the potential association between MMP-9 gene polymorphism and susceptibility to Primary Open Angle Glaucoma development in Egyptian patients The main question it aims to

Conditions

Primary Open Angle Glaucoma (POAG)

Keywords

Primary Open Angle Glaucoma; POAG; Gene Polymorphism; MMP-9; Matrix Metalloproteinase-9 Gene Polymorphism

Outcome Measures

Primary Outcomes (1)

• Matrix metalloproteinase-9 gene polymorphism

  Matrix metalloproteinase-9 gene polymorphism by polymerase chain reaction

  14 months

Study Arms (2)

Control Group

Normal healthy volunteers aged \> 30 years

Genetic: genotyping assay by polymerase chain reaction

Experimental Group

Patients aged \>30 years and diagnosed with Primary Open Angle Glaucoma

Genetic: genotyping assay by polymerase chain reaction

Interventions

genotyping assay by polymerase chain reaction GENETIC

Blood sample will be obtained from all participants by withdrawing 3 mL of blood via venipuncture in ethylenediaminetetraacetic acid tube. Thereafter, DNA extraction will be obtained after centrifugation to be used for genotyping assay of MMP-9 gene with polymerase chain reaction

Control Group; Experimental Group

Eligibility Criteria

• Age: 30 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with Primary Open Angle Glaucoma in Department of ophthalmology in Sohag University Hospitals and healthy controls of matched age and sex

You may qualify if:

• Men and women older than 30 years
• Primary open angle glaucoma as evidenced from characteristic visual field loss and optic disc cupping (POAG group)
• Healthy subjects matched by age, sex and ethnicity to the POAG patients group (control group)

You may not qualify if:

• Exfoliation glaucoma, pigmentary glaucoma
• History of acute angle closure

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag University Hosipital

Sohag, Sohag Governorate, 82525, Egypt

Location

Related Publications (3)

• Grzybowski A, Och M, Kanclerz P, Leffler C, Moraes CG. Primary Open Angle Glaucoma and Vascular Risk Factors: A Review of Population Based Studies from 1990 to 2019. J Clin Med. 2020 Mar 11;9(3):761. doi: 10.3390/jcm9030761.

  PMID: 32168880 BACKGROUND

• Liu Y, Allingham RR. Major review: Molecular genetics of primary open-angle glaucoma. Exp Eye Res. 2017 Jul;160:62-84. doi: 10.1016/j.exer.2017.05.002. Epub 2017 May 10.

  PMID: 28499933 BACKGROUND

• Zhao F, Fan Z, Huang X. Role of matrix metalloproteinase-9 gene polymorphisms in glaucoma: A hospital-based study in Chinese patients. J Clin Lab Anal. 2020 Mar;34(3):e23105. doi: 10.1002/jcla.23105. Epub 2019 Nov 12.

  PMID: 31713905 BACKGROUND

MeSH Terms

Conditions

Glaucoma, Open-Angle

Condition Hierarchy (Ancestors)

Glaucoma; Ocular Hypertension; Eye Diseases

Central Study Contacts

Thomas Talaat Nageh, Demonstrator

CONTACT

20 1276890796; thomas.talaat@med.sohag.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Demonstrator

Study Record Dates

• First Submitted: August 2, 2025
• First Posted: August 13, 2025
• Study Start (Estimated): June 1, 2026
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): February 1, 2027
• Last Updated: August 13, 2025

Record last verified: 2025-08

Locations

EG (1)