Risk Factors of Ventilator-Associated Pneumonia in Critically Ill Population of Alexandria

NCT07116382 | Completed DMC

• 1 other identifier: VAPRISK
• Study Type: observational
• Target: 180
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the study is to compare cases of ventilator-associated pneumonia with matched controls of mechanically ventilated patients to identify any relevant independent risk factors for ventilator-associated pneumonia. All adult (≥ 18 years) mechanically ventilated patients \> 48 hours who are diagnosed with ventilator-associated pneumonia are considered as cases. The control group are mechanically ventilated patients and matching with cases regarding their age, gender, and duration of mechanical ventilation.

Conditions

Ventilator Associated Pneumonia

Keywords

Critical Care; Ventilator Associated Pneumonia; Risk Factors

Outcome Measures

Primary Outcomes (1)

• In-ICU mortality

  All-Cause Mortality Rate

  Up to ICU discharge for a maximum of 3 months

Study Arms (2)

VAP group

All adult (≥ 18 years) mechanically ventilated patients \> 48 hours who are diagnosed with ventilator-associated pneumonia are considered as cases. All possible risk factors for VAP are investigated.

Matched Control group

Mechanically ventilated (≥ 48 hours) patients and matching with cases regarding their age, gender, and duration of MV. All possible risk factors for VAP are investigated.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adults diagnosed with VAP (cases group) and matched controls without VAP.

You may qualify if:

• All adult (≥ 18 years) mechanically ventilated patients \> 48 hours who are diagnosed with VAP (Case Group).
• The control group is mechanically ventilated (≥ 48 hours) patients and matched with cases regarding their gender, age, and duration of MV.

You may not qualify if:

• Patients with pneumonia prior to MV and those developing pneumonia within 48 hours are excluded from the study.

Sponsors & Collaborators

• Suez Canal University: lead

Study Sites (1)

AMUH

Alexandria, Egypt

Location

MeSH Terms

Conditions

Pneumonia, Ventilator-Associated

Condition Hierarchy (Ancestors)

Healthcare-Associated Pneumonia; Cross Infection; Infections; Pneumonia; Respiratory Tract Infections; Lung Diseases; Respiratory Tract Diseases; Iatrogenic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Researcher, Public Health and Community Medicine Department

Study Record Dates

• First Submitted: August 2, 2025
• First Posted: August 11, 2025
• Study Start: February 20, 2025
• Primary Completion: May 20, 2025
• Study Completion: May 20, 2025
• Last Updated: August 11, 2025

Record last verified: 2025-08

Locations

EG (1)