NCT07115810

Brief Summary

The goal of this observational study is to compare the clinical outcomes, molecular features, and immune profiles of patients with synchronous and metachronous distant metastases in Saudi cohort with well characterized differentiated thyroid cancer. The main question it aims to answer is whether timing of metastasis is associated with distinct prognostic or biological behavior in differentiated thyroid cancer from a large Middle Eastern cohort

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
178

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Jan 1988

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 1988

Completed
31 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2018

Completed
6 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2024

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

August 4, 2025

Completed
7 days until next milestone

First Posted

Study publicly available on registry

August 11, 2025

Completed
Last Updated

August 11, 2025

Status Verified

August 1, 2025

Enrollment Period

31 years

First QC Date

August 4, 2025

Last Update Submit

August 4, 2025

Conditions

Differentiated Thyroid Cancer

Keywords

synchronous metastasismetachronous metastasisprognosis

Outcome Measures

Primary Outcomes (1)

  • Overall survival

    5 years

Secondary Outcomes (1)

  • Thyroid cancer-specific survival

    5 years

Study Arms (1)

Metastatic DTC

Other: No additional drugs(control Group)

Interventions

No additional drugs(control Group)OTHER

No intervention

Metastatic DTC

Eligibility Criteria

Sexall
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients with metastatic differentiated thyroid cancer diagnosed at King Faisal Specialist Hospital \& Research Centre in Riyadh, Saudi Arabia

You may qualify if:

  • Synchronous or metachronous distant metastases

You may not qualify if:

  • Not DTC
  • No distant metastases

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Dr

Study Record Dates

First Submitted

August 4, 2025

First Posted

August 11, 2025

Study Start

January 1, 1988

Primary Completion

December 31, 2018

Study Completion

December 31, 2024

Last Updated

August 11, 2025

Record last verified: 2025-08

Data Sharing

IPD Sharing
Will not share

IPD will not be shared due to local regulations in Saudi Arabia