NCT07110285

Brief Summary

To compare the number of mature oocytes following a GnRH antagonist in-vitro fertilization stimulation cycle when comparing trigger day timing decision by physicians versus an artificial intelligence-based algorithm

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
180

participants targeted

Target at P75+ for not_applicable

Timeline
25mo left

Started May 2025

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress32%
May 2025May 2028

Study Start

First participant enrolled

May 21, 2025

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

July 31, 2025

Completed
7 days until next milestone

First Posted

Study publicly available on registry

August 7, 2025

Completed
1.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2027

Expected
1.1 years until next milestone

Study Completion

Last participant's last visit for all outcomes

May 21, 2028

Last Updated

January 12, 2026

Status Verified

May 1, 2025

Enrollment Period

1.9 years

First QC Date

July 31, 2025

Last Update Submit

January 8, 2026

Conditions

IVF Outcomes

Keywords

Trigger day decisionIn-vitro fertilizationMature oocytesArtifical intelligence-based algorithm

Outcome Measures

Primary Outcomes (1)

  • Mature oocyte yield

    The number of mature oocytes collected during a single egg retrieval cycle

    2 years

Secondary Outcomes (1)

  • Oocyte yield

    2 years

Study Arms (2)

Physician-based trigger day timing decision

NO INTERVENTION

Trigger day timing is decided on by the treating physician

Artificial intelligence-based algorithm trigger day timing decision

EXPERIMENTAL

Trigger day timing decision by an artificial intelligence-based algorithm

Other: Artificial intelligence-based algorithm

Interventions

Artificial intelligence-based algorithmOTHER

Trigger day timing decision by an artificial intelligence-based algorithm

Artificial intelligence-based algorithm trigger day timing decision

Eligibility Criteria

Age18 Years - 45 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • All patients undergoing an ovarian stimulation cycle utilizing the GnRH antagonist protocol for oocyte cryopreservation or for fertilization via intracytoplasmic sperm injection (ICSI) (any treatment where oocytes are denuded and maturity may be assessed).

You may not qualify if:

  • Loss to follow-up, patient retracts consent to participate

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Herzliya Medical Center

Herzliya, 74077, Israel

RECRUITING

Study Officials

  • Ariel Hourvitz, MD

    Herzeliya Medical Center, Israel

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Michal Youngster, MD

CONTACT

+972-50-643-0111michalyo@gmail.com

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

July 31, 2025

First Posted

August 7, 2025

Study Start

May 21, 2025

Primary Completion (Estimated)

May 1, 2027

Study Completion (Estimated)

May 21, 2028

Last Updated

January 12, 2026

Record last verified: 2025-05

Data Sharing

IPD Sharing
Will share

Data regarding patient demographics, characteristics and cycle outcomes (anynomized)

Shared Documents
STUDY PROTOCOL
Time Frame
From the beginning until the end of recruitment

Locations

IL(1)