NCT07108374|Enrolling By Invitation
Implementation of Red Blood Cell Transfusion Recommendations in the Pediatric Intensive Care Unit
TRIP
Transfusion Recommendations Implemented in the PICU (TRIP)
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TRIP
Transfusion Recommendations Implemented in the PICU (TRIP)
Sponsor study identifier
Secondary identifiers
OTHER_GRANT · AHRQ
interventional
200
1 country
2
Study Start
November 30, 2024
Actual (reported)Primary Completion
December 31, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
February 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Evidence demonstrates that the risks of red blood cell transfusions outweigh benefits in many patients who are hospitalized in the pediatric intensive care unit with increased risk of organ dysfunction, infection, delirium, and death. Recommendations have been developed to restrict transfusion in patients who are unlikely to benefit; however, these recommendations have not been consistently adopted into clinical practice. This study examines use of targeted efforts (implementation strategies) to improve implementation of the recommendations, with a goal of reducing unnecessary transfusions and improving patient outcomes in critically ill children.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
February 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 30, 2024
Actual (reported)June 27, 2025
Actual (reported)August 7, 2025
Actual (reported)December 31, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
February 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Mean change from baseline in transfusion recommendation adherence at 18 months (evidence-based threshold alert)
The investigators will assess the mean rate of nonadherent transfusions at monthly intervals in the pre- (12 months prior to CCDS tool initiation) and post-implementation period (18 months following CCDS tool initiation).
18 months
Mean change from baseline in transfusion recommendation adherence at 18 months (transfusions that require clinical judgement)
18 months
Reach of computerized clinical decision support (CCDS) tools
18 months
Unintended consequences of CCDS tools - Surveys - 6 months
Provider surveys at 6 months post-CCDS implementation
Unintended consequences of CCDS tools - Surveys - 12 months
Provider surveys at 12 months post-CCDS implementation
Unintended consequences of CCDS tools - Interviews 6 months
Provider surveys and interviews at 6 months post-CCDS implementation
Five implementation strategies will be employed in this study to enhance use of the blood transfusion recommendations. These include 1) building consensus, 2) provider education, 3) identifying and empowering champions ,4) use of computerized clinical decision support tools, and 5) provide quantitative metric-based feedback. Strategies 1-3 will occur prior to initiation of CCDS tools. All patients admitted to the PICU following the date of CCDS tool initiation will be considered to be part of the post-implementation phase. The investigators will collect data from the EHR on CCDS use and conduct provider surveys and interviews following CCDS tool initiation. Surveys and interviews will be both be conducted at 6 and 12 months post-CCDS tool initiation. Process and outcomes measures will be assessed before an after use of the implementation strategies.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Lucile Packard Children's Hospital, Stanford University
Palo Alto, California, 94304, United States
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
First Submitted
June 27, 2025
Trial of Indication-Based Transfusion of Red Blood Cells in ECMO
Contact the study team to confirm eligibility.
First Posted
August 7, 2025
Study Start
November 30, 2024
Actual (reported)Primary Completion
December 31, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
February 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
August 7, 2025
Record last verified: 2025-07
Because PEDSnet is not a public data repository, individual-level datasets are not typically released publicly outside of the network. Due to the complexity and privacy concerns associated with electronic health record data, certified PEDSnet data scientists lead the execution of all data analyses. While the data generated for this study cannot be shared publicly, our study team will make every effort to assist interested investigators and teams in leveraging the PEDSnet network to collaborate to obtain the entire dataset from this study or subset of data necessary for conducting secondary analyses or in answering a new, intended study question. Our study team will provide a final report(s) on our research findings and the investigators will relate that data can be made available for subsequent analyses through PEDSnet and provide necessary contact information to submit a Collaboration Request through PEDSnet or Dr. Steffen.
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Source: ClinicalTrials.gov.
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