Prosthetic Joint Infection : Lessons From Deceased Patients in Critical Care.

NCT07107685 | Recruiting

• 1 other identifier: APHP250872
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

This is an observational, retrospective, multicenter study based on the use of demographic, clinical and biological data from deceased patients admitted between 2018 and 2022 to critical care with a principal or associated diagnosis of joint prosthesis infection. Data from this study will be combined with that from the OASIS study (APHP241174/ ID-RCB: 2024-A01769-38) concerning osteoarticular sepsis on prosthetic material in critical care of living patients. The aim of this study is to improve our knowledge of the profile, care trajectories and outcomes of patients hospitalized in critical care in the context of osteoarticular material sepsis. The results of the study could help identify at-risk populations and improve management strategies for patients with osteoarticular sepsis.

Conditions

Osteoarticular Infections; Intensive Care Patients; Prosthetic Joint Infection

Keywords

Osteoarticular sepsis; sepsis; osteoarticular prothetis; intensive care; critical care; prosthetic joint infection

Outcome Measures

Primary Outcomes (1)

• Epidemiological description of deceased patients

  Demographic data, medical history, history of Periprosthetic Joint Infection (timing, diagnosis, surgery, antibiotics), data in intensive care unit (leng of stay, organ failure, drugs and mechanical support, biological data) and outcome (time of death within 2 years after admission to Intensive Care Units).

  2 years

Secondary Outcomes (3)

• Composite endpoint reflecting poor clinical outcome

  2 years

• Mortality at 2 years

  2 years

• Epidemiological description based on the number (n) and proportion (%) of bacterial strains found in samples collected during the operation.

  2 years

Interventions

Global cohort OTHER

All deceased patients admitted to intensive care during the study period and satisfying the eligibility criteria.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Critical care patients (intensive care and continuing care), admitted between 2018 and 2022 with a principal or associated diagnosis of joint prosthesis infection, who have since died.

You may qualify if:

• Patient aged 18 years or older.
• Hospitalization in critical care (intensive care unit or continuing care unit) between 2018 and 2022, lasting at least 48 hours, with a prosthetic joint infection (hip, knee, or shoulder prosthesis infection) as the primary or associated diagnosis.
• Deceased patient who had not refused data processing.

You may not qualify if:

• Infection involving osteosynthesis material
• Infection involving spinal instrumentation
• Patient with multiple infected prostheses
• Recurrence of prosthetic infection with the same microorganism as a previous episode
• Patient under legal protection
• Pregnant or breastfeeding patient
• Patient deprived of liberty

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead

Study Sites (1)

Hôpital Lariboisière

Paris, France, 75010, France

RECRUITING

MeSH Terms

Conditions

Sepsis

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Carine PARE

  Assistance Publique - Hôpitaux de Paris

  STUDY DIRECTOR

Central Study Contacts

Benjamin SOYER, MD, Msc

CONTACT

+33 1 49 95 85 15; benjamin.soyer@aphp.fr

Benjamin CHOUSTERMAN, MD, PhD

CONTACT

benjamin.chousterman@aphp.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 9, 2025
• First Posted: August 6, 2025
• Study Start: September 24, 2025
• Primary Completion: March 24, 2026
• Study Completion: March 24, 2026
• Last Updated: October 1, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)