Early STratification of Acute ARThritis

NCT07106931 | Recruiting

• 1 other identifier: REC671173
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

The prospective observational study "Early STratification of acute inflammatory ARThritis" (START) aims to build a platform for identification of markers for early stratification of inflammatory arthritis to ensure timely diagnosis and correct initial treatment. Management of early-stage inflammatory arthritis is a daily challenge for the rheumatologist and encompasses a range of conditions. Stratification is needed both for optimal diagnostics and for personalising therapy, but is hampered by a lack of tools. Current evaluation is inadequate for early diagnosis and treatment of inflammatory joint diseases as well as for timely diagnosis of infections. The clinical role of novel biomarkers needs to be investigated in large patient samples. In the START study, an extensive data collection will be performed to build a platform for identification and validation of biomarkers for stratification of early-stage inflammatory arthritis. The study has an ambitious goal of improving patient care by increased understanding of the disease. The project applies a unique multitude of approaches to characterisation of patients, including modern imaging techniques, analyses of synovial fluid and -biopsies, genetic and epigenetic markers, proteomics, microbiota analyses and immunological markers. The results will enable clinicians to make better informed treatment decisions for the individual patient with early-stage inflammatory arthritis.

Conditions

Arthritis

Keywords

early onset arthritis

Outcome Measures

Primary Outcomes (1)

• Final diagnosis

  Number of patients with a final diagnoses of the differnent forms of arthritis assed by the ICD-10 codes given by the investigator

  12 months

Interventions

This is an observational study with no intervention OTHER

This is an observational study with no intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients refered to the outpatient clinic

You may qualify if:

• Arthritis\* in one or more joints of less than 12 weeks' duration\*\*
• Adult patients (\> 18 years) capable of understanding and signing an informed consent form

You may not qualify if:

• Swollen joint related to trauma
• Subject not capable of adhering to the study protocol

Sponsors & Collaborators

• Diakonhjemmet Hospital: lead
• Oslo University Hospital: collaborator

Study Sites (1)

Diakonhjemmet Hospital

Oslo, 0319, Norway

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Blood, synovial fluid and synovial biopsies

MeSH Terms

Conditions

Arthritis

Condition Hierarchy (Ancestors)

Joint Diseases; Musculoskeletal Diseases

Central Study Contacts

Silje W Syversen, MD PhD

CONTACT

+4792040315; s.w.syversen@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD PhD

Study Record Dates

• First Submitted: June 3, 2025
• First Posted: August 6, 2025
• Study Start: November 5, 2024
• Primary Completion (Estimated): December 31, 2044
• Study Completion (Estimated): December 31, 2044
• Last Updated: August 6, 2025

Record last verified: 2025-08

Locations

NO (1)