Latin American Testing of the Inventory for Risk in Suicidal Crisis Syndrome (LATIR-SCS)

NCT07103850 | Recruiting

• 1 other identifier: 071124
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational validation study is to assess the psychometric properties of the Spanish versions of the Suicide Crisis Inventory-Revised (SCS-2) and the Suicidal Crisis Syndrome Checklist (SCS-C) in adults recently hospitalized for suicidal behavior in Chile. The study aims to determine whether the Spanish versions of the SCS-2 and SCS-C demonstrate adequate internal consistency, construct validity, interrater reliability, and test-retest stability, and whether these tools validly assess imminent suicide risk in a Spanish-speaking psychiatric population. Clinical assessments using the SCS-2 and SCS-C will be compared with established diagnostic and functional measures, including the Mini International Neuropsychiatric Interview (MINI), the Sheehan Disability Scale (SDS), and the Sheehan Suicidality Tracking Scale (S-STS), to evaluate convergent and discriminant validity. Participants will complete the SCS-2 and SCS-C at both admission and discharge from a psychiatric intensive care unit, undergo structured interviews and functional assessments, be evaluated by two independent raters for interrater reliability, and be reassessed within a short time interval to measure test-retest reliability. Follow-up contacts at 7 and 30 days post-discharge will be used to assess suicidal behavior outcomes. This is the first study to culturally adapt and validate these suicide-specific instruments in Latin America.

Conditions

Suicidal Crisis

Keywords

Suicidal Crisis Syndrome

Outcome Measures

Primary Outcomes (1)

• Suicidal Event Within 30 Days Post-Discharge

  Description: Occurrence of a suicidal event within 30 days after discharge, defined as any of the following: 1. Deliberate self-inflicted violence resulting in actual or potential injury, with explicit or implicit evidence of suicidal intent; 2. Preparatory behaviors for suicide; 3. Aborted suicide attempts; 4. Interrupted suicide attempts; or 5. Suicidal ideation leading to emergency consultation or referral. Assessment Method: Patient phone follow-up and review of clinical records Measure Type: Clinical outcome (binary: presence/absence of suicidal event)

  30 days post-discharge

Secondary Outcomes (11)

• Suicidal Event Within 7 Days Post-Discharge

  7 days post-discharge

• Convergent Validity with the Sheehan Suicidality Tracking Scale (S-STS)

  Baseline

• Convergent Validity with the Sheehan Disability Scale (SDS)

  Baseline

• Discriminant Validity with Psychiatric Diagnoses on the MINI

  Baseline

• Test-Retest Reliability of the SCS-2

  Up to 48 hours from baseline

Study Arms (2)

SCS+ Cohort

Definition: Patients who meet the diagnostic criteria for Suicidal Crisis Syndrome using the clinician-administered SCS-C.

Diagnostic Test: Suicidal Crisis Syndrome Checklist (SCS-C); Diagnostic Test: Suicide Crisis Inventory-Revised (SCS-2)

SCS- Cohort

Definition: Patients hospitalized for suicidal behavior who do not meet diagnostic criteria for SCS on the SCS-C.

Diagnostic Test: Suicidal Crisis Syndrome Checklist (SCS-C); Diagnostic Test: Suicide Crisis Inventory-Revised (SCS-2)

Interventions

Suicidal Crisis Syndrome Checklist (SCS-C) DIAGNOSTIC_TEST

The Suicidal Crisis Syndrome Checklist (SCS-C) is a clinician-rated tool designed to diagnose Suicidal Crisis Syndrome (SCS), a suicide-specific state associated with imminent risk. It includes Criterion A (entrapment)-a required symptom-and Criterion B, which requires at least one symptom from each of four domains: affective disturbance, loss of cognitive control, hyperarousal, and social withdrawal. The checklist offers a structured assessment for identifying acute suicide risk, complementing traditional risk evaluations.

SCS+ Cohort; SCS- Cohort

Suicide Crisis Inventory-Revised (SCS-2) DIAGNOSTIC_TEST

The Suicide Crisis Inventory-Revised (SCS-2) is a 61-item self-report scale developed to assess the severity of Suicidal Crisis Syndrome (SCS), a clinical state associated with imminent suicide risk. Items are rated on a Likert scale and grouped into five empirically derived factors: entrapment, affective disturbance, loss of cognitive control, hyperarousal, and social withdrawal. The SCS-2 has shown strong internal consistency and predictive validity for suicidal behavior within weeks of discharge. It is currently undergoing cultural adaptation and psychometric validation in Spanish for use in high-risk psychiatric populations in Chile.

SCS+ Cohort; SCS- Cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult psychiatric inpatients (≥18 years old) hospitalized in the Psychiatric Intensive Care Unit (UHCIP) of the Complejo Asistencial Dr. Sótero del Río (CASR), Santiago, Chile. All participants are admitted due to a recent suicidal event, including suicide attempts, preparatory behaviors, interrupted or aborted attempts, or suicidal ideation requiring emergency care. The sample includes individuals with diverse psychiatric diagnoses and varying levels of acute suicide risk. Participants must be clinically stable, capable of providing informed consent, and fluent in Spanish. The population is representative of high-risk individuals typically seen in public psychiatric emergency settings in Latin America.

You may qualify if:

• Age ≥ 18 years
• Currently hospitalized in the Psychiatric Intensive Care Unit (UHCIP) at Complejo Asistencial Dr. Sótero del Río (CASR)
• Hospitalization due to a recent suicidal event, defined as at least one of the following:
• Deliberate self-inflicted violence with actual or potential injury and explicit or implicit suicidal intent
• Preparatory behaviors for suicide
• Aborted suicide attempts
• Interrupted suicide attempts
• Suicidal ideation leading to emergency consultation or referral
• Able to provide informed consent
• Judged competent to participate by the treating psychiatrist
• Fluent in Spanish

You may not qualify if:

• Presence of severe psychotic symptoms
• Qualitative or quantitative disturbance of consciousness (e.g., delirium, coma)
• Severe psychomotor agitation requiring mechanical restraint
• Inability to understand or complete study procedures (e.g., due to cognitive impairment or language barriers)

Sponsors & Collaborators

• University Diego Portales: lead
• Hospital Dr Sotero del Rio: collaborator

Study Sites (1)

Complejo Asistencial Sotero del Rio

Santiago, Santiago Metropolitan, Chile

RECRUITING

Central Study Contacts

Francisco Villalón, M.D

CONTACT

+56988996001; villalon.fj@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 21, 2025
• First Posted: August 5, 2025
• Study Start: August 12, 2025
• Primary Completion: April 30, 2026
• Study Completion: April 30, 2026
• Last Updated: September 19, 2025

Record last verified: 2025-09

Locations

CL (1)