L-PRF vs Connective Tissue With Customized Healing Abutment in Immediate Implant Placement
Evaluation of Soft and Hard Tissue Augmentation by Connective Tissue Graft or Leukocyte-Platelet Rich Fibrin in Immediate Implant Placement With Customized Healing Abutment: A Randomized Controlled Clinical Trial.
1 other identifier
interventional
16
1 country
1
Brief Summary
comparison between L-prf and connective tissue with dental implant
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Aug 2025
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 30, 2025
CompletedFirst Posted
Study publicly available on registry
August 5, 2025
CompletedStudy Start
First participant enrolled
August 5, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 10, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
August 20, 2027
August 14, 2025
August 1, 2025
1 year
July 30, 2025
August 10, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Patient-reported pain experience
Pain experience after surgery is daily measured by the patients using a visual analogue scale (VAS) in the first postoperative 7 days, with Day 0 being the day of the surgery. Before going to sleep, patients will be asked to mark the VAS that best represented the average pain they had experienced during the day.
first 7 days after surgery
Pink aesthetic score
Parameters are : 0,1 and 2. Mesial papilla : 0 ( Missing ) , 1 ( Incomplete ) and 2 ( Complete ). Distal Papilla : 0 ( Missing ) , 1 ( Incomplete ) and 2 ( Complete ). Tissue contour : 0 ( Unnatural) , 1 ( virtually natural ) and 2 ( natural). Gingival level : 0 ( \>2mm) , 1 ( 1-2mm ) and 2 ( 1 mm). Alveolar process : 0 ( clearly resorbed ) , 1 ( slightly resorbed ) and 2 ( no difference). Coloring : 0 ( clear difference ) , 1 ( slight difference ) and 2 ( no difference). Texture : 0 ( clear difference ) , 1 ( slight difference ) and 2 ( no difference).
before surgery, 3 months and 6 months after surgery
crestal bone loss
distance from implant shoulder to marginal bone
preoperative and 6 months post operative
Secondary Outcomes (3)
Gingival thickness
pre opearative, 3 and 6 months post operative
probing pocket depth
preoperative , 3 and 6 months post operative
keratinized tissue width
preoperative , 3 and 6 months post operative
Study Arms (2)
Connective tissue with dental implant and customized healing abutment
ACTIVE COMPARATORConnective tissue with dental implant and customized healing abutment
L-PRF with dental implant and customized healing abutment
EXPERIMENTALL-PRF with dental implant and customized healing abutment
Interventions
L-PRF with dental implant and customized healing abutment
Connective tissue with dental implant and customized healing abutment
Eligibility Criteria
You may qualify if:
- Intact labial/buccal bone plate
- The presence of non-restorable single-rooted maxillary centrals, canines or premolars.
- Sufficient bone volume.
- Good oral hygiene.
- Nonsmokers.
- Sufficient bone width (≥ 1 mm) in the buccal plate of the remaining bone to place an implant confirmed by cone beam computer tomography (CBCT).
You may not qualify if:
- Insufficient bone volume.
- Active infection.
- Patients on chemotherapy or radiotherapy.
- Patients who have systemic disorders {uncontrolled diabetes mellitus, autoimmune disease, …etc},
- Pregnant patients,
- Patients with bone diseases
- Presence of periapical pathology.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Kafrelsheikh University
Kafr ash Shaykh, Kafrelsheikh, Egypt
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- General dentist
Study Record Dates
First Submitted
July 30, 2025
First Posted
August 5, 2025
Study Start
August 5, 2025
Primary Completion (Estimated)
August 10, 2026
Study Completion (Estimated)
August 20, 2027
Last Updated
August 14, 2025
Record last verified: 2025-08