Left Atrial Strain Assessment in Ischemic Stroke Patients

NCT07102693 | Completed

• 1 other identifier: CBH 024/23
• Study Type: observational
• Target: 468
• Locations: 1 country
• Sites: 1

Brief Summary

This study is investigating a potential link between a novel measurement made on cardiac ultrasound and the risk of ischemic stroke in patients with a normal heart rhythm. The novel measurement is called left atrial strain. It uses speckle tracking echocardiography to measure the muscle function of the left atrium, one of the cardiac chambers. Investigators investigated whether patients with lower function of this chamber are at a higher risk of developing stroke from blood clots traveling to the brain. It is already known that patients with an irregular heart rhythm known as atrial fibrillation are at higher risk of these types of strokes. Investigators wanted to determine if there is a similar association in patients with normal heart rhythm but low left atrial strain.

Conditions

Ischemic Stroke; Left Atrial Strain; Sinus Rhythm

Keywords

left atrial strain

Outcome Measures

Primary Outcomes (1)

• Correlation between left atrial strain and acute ischaemic stroke

  This correlation will be adjusted for common stroke risk factors such as age, gender, hypertension, smoking, dyslipidaemia, and diabetes.

  2 weeks

Study Arms (2)

Patients with Acute Ischemic Stroke

Patients presenting to the emergency department with FAST positive symptoms who are proven to have acute ischaemic stroke on neuroimaging.

Patients without Acute Ischaemic Stroke

Patients presenting to the emergency department with FAST positive symptoms who do not have evidence of acute ischaemic stroke on neuroimaging and an alternative cause of their FAST symptoms is found

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients presenting to the emergency department with FAST positive symptoms suspicious for an acute stroke.

You may qualify if:

• Emergency department presentation with FAST positive symptoms
• Neuroimaging performed as part of stroke workup
• Echocardiogram performed during index admission

You may not qualify if:

• Any history of atrial fibrillation prior or during admission
• Age below 18 years of age
• No echocardiogram or echocardiogram images not of sufficient quality to perform left atrial strain analysis
• At least moderate mitral regurgitation
• ASD or PFO

Sponsors & Collaborators

• Connolly Hospital Blanchardstown: lead

Study Sites (1)

Connolly Hospital Blanchardstown

Dublin, Co. Dublin, D15 X40D, Ireland

Location

MeSH Terms

Conditions

Ischemic Stroke

Condition Hierarchy (Ancestors)

Stroke; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 30, 2025
• First Posted: August 5, 2025
• Study Start: July 15, 2024
• Primary Completion: June 1, 2025
• Study Completion: June 1, 2025
• Last Updated: August 12, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will share

Locations

IE (1)