The Effect of Single Lung Ventilation Duration on Postoperative Pulmonary Complications in Thoracic Surgery

NCT07100860 | Recruiting

• 1 other identifier: OLV_PPC
• Study Type: observational
• Target: 134
• Locations: 1 country
• Sites: 1

Brief Summary

This observational study investigates the relationship between the duration of single-lung ventilation (SLV) and the incidence of postoperative pulmonary complications (PPCs) such as pneumonia, pneumothorax, hemothorax, acute lung injury, and acute respiratory distress syndrome (ARDS) in adult patients undergoing thoracic surgery. A total of 134 patients aged 18-85 years, scheduled for thoracic surgery requiring SLV, will be monitored. Data including SLV duration, perioperative parameters, and postoperative pulmonary outcomes will be analyzed.

Conditions

One Lung Ventilation; Ards; Postoperative Pulmonary Complications; Postoperative Pulmonary Atelectasis

Keywords

postoperative pulmonary complications; one lung ventilation

Outcome Measures

Primary Outcomes (1)

• Postopertive Pulmonary Complications

  Postoperative pulmonary complications (PPCs) are defined as respiratory events occurring within the first seven days following thoracic surgery, which negatively impact patient outcomes. In this study, PPCs include pneumonia, pneumothorax, hemothorax, acute lung injury, acute respiratory distress syndrome (ARDS), prolonged oxygen requirement, unplanned reintubation, and the need for non-invasive ventilation. These complications will be identified through clinical assessment, arterial blood gas analysis, and postoperative imaging such as chest X-rays. Each case will be evaluated using predefined diagnostic criteria to ensure consistency. The incidence of PPCs will be analyzed in relation to the duration of intraoperative single-lung ventilation.

  postoperative 7 days

Interventions

One-Lung ventilation PROCEDURE

In this observational study, the naturally occurring duration of intraoperative single-lung ventilation (SLV) during thoracic surgery will be recorded. No intervention is applied or modified for research purposes. The exposure of interest is the total duration (in minutes) of SLV, which will be timed from initiation to termination during surgery. This variable will be analyzed in relation to postoperative pulmonary complications.

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will consist of adult patients aged 18 to 85 years who are scheduled to undergo thoracic surgery at Etlik City Hospital and require OLV during the procedure. Patients will be included if they meet the eligibility criteria of being over 18 years old, undergoing thoracic surgery, receiving intraoperative OLV, and providing informed consent to participate in the study. Patients will be excluded if they are part of the pediatric age group, do not require OLV, or decline participation. A total of 134 eligible patients will be prospectively enrolled and followed for seven days postoperatively to assess the occurrence of pulmonary complications.

You may qualify if:

• Age ≥18 years Undergoing thoracic surgery OLV planned during the procedure

You may not qualify if:

• Pediatric patients Patients not requiring OLV Previous thoracic surgery

Sponsors & Collaborators

• Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital: lead

Study Sites (1)

Hazal Ekin GÜRAN AYTUĞ

Ankara, Ankara, 06810, Turkey (Türkiye)

RECRUITING

Related Publications (2)

• Miskovic A, Lumb AB. Postoperative pulmonary complications. Br J Anaesth. 2017 Mar 1;118(3):317-334. doi: 10.1093/bja/aex002.

  PMID: 28186222 BACKGROUND

• Kiss T, Bluth T, Gama de Abreu M. [Does intraoperative lung-protective ventilation reduce postoperative pulmonary complications?]. Anaesthesist. 2016 Aug;65(8):573-9. doi: 10.1007/s00101-016-0198-8. German.

  PMID: 27392439 BACKGROUND

MeSH Terms

Conditions

Acute Lung Injury; Pulmonary Atelectasis

Interventions

One-Lung Ventilation

Condition Hierarchy (Ancestors)

Lung Injury; Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Respiration, Artificial; Airway Management; Therapeutics

Study Officials

• Hazal EG AYTUĞ

  Consultant Anesthesiologist

  STUDY DIRECTOR

Central Study Contacts

Hazal EG AYTUĞ

CONTACT

05078448449; drekinguran@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Consultant Anesthesiologist

Study Record Dates

• First Submitted: July 28, 2025
• First Posted: August 3, 2025
• Study Start: January 1, 2025
• Primary Completion: December 1, 2025
• Study Completion: January 1, 2026
• Last Updated: December 18, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)