'Bubble Time' in Pulmonary Embolism

NCT07098546 | Active Not Recruiting

• 1 other identifier: Mumin Murat YAZICI
• Study Type: observational
• Target: 250
• Locations: 1 country
• Sites: 1

Brief Summary

The study will be multi-centre and prospectively planned. All patients who undergo contrast-enhanced computed tomography in the emergency department with a preliminary diagnosis of pulmonary embolism and who do not meet the exclusion criteria will be included in the study. Informed consent will be obtained from all patients prior to the study. Patients included in the study will undergo bedside ultrasound to assess bubble time, right ventricle-left ventricle ratio, presence of a septal defect, and tricuspid insufficiency, and the diagnostic value of these findings will be evaluated. The bedside ultrasound will be part of the emergency department critical care examination, will not incur any costs for the institution, and will be performed and evaluated by an emergency medicine specialist and assistant.

Conditions

Tanısal değerlilik

Keywords

pulmonary embolism; bubble time; pocus

Outcome Measures

Primary Outcomes (2)

• Bubble time

  The diagnostic value of bubble time

  through study completion, an average of six months

• bubble time in pulmonary embolism

  The diagnostic value of bubble time in pulmonary embolism

  through study completion, an average of six months

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

1.000.000

You may qualify if:

• \- All patients presenting to the emergency department with any symptoms, undergoing pulmonary CT angiography due to suspected pulmonary embolism or evaluated as having a strong likelihood of embolism when CT cannot be performed will be included in the study.

You may not qualify if:

• Patients under the age of 18
• Patients with a severe history of tricuspid insufficiency
• Patients with a severe of pulmonary hypertension
• Patients with a severe of right heart failure
• Patients without an echocardiographic report approved by cardiology within 48 hours after emergency admission
• Patients in whom ultrasonographic measurements cannot be performed
• Patients who refuse diagnosis and treatment voluntarily

Sponsors & Collaborators

• Recep Tayyip Erdogan University Training and Research Hospital: lead
• Marmara University Pendik Training and Research Hospital: collaborator
• Gazi University: collaborator
• Akdeniz University Hospital: collaborator

Study Sites (1)

Recep Tayyip Erdoğan Üniversitesi Rize Eğitim ve Araştırma Hastanesi

Rize, Merkez, 53020, Turkey (Türkiye)

Location

Related Publications (1)

• Cohen A, Li T, Bielawa N, Nello A, Gold A, Gorlin M, Nelson M, Carlin E, Rolston D. Right Ventricular "Bubble Time" to Identify Patients With Right Ventricular Dysfunction. Ann Emerg Med. 2024 Aug;84(2):182-194. doi: 10.1016/j.annemergmed.2024.02.005. Epub 2024 Apr 10.

  PMID: 38597847 BACKGROUND

MeSH Terms

Conditions

Pulmonary Embolism

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Embolism; Embolism and Thrombosis; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Emergency Specialist, Principal Investigator

Study Record Dates

• First Submitted: July 4, 2025
• First Posted: August 1, 2025
• Study Start: July 3, 2025
• Primary Completion: October 15, 2025
• Study Completion: November 30, 2025
• Last Updated: August 3, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)