Comparison of MIPPED-C and Surgical Necrosectomy in Pancreatic Necrosis Outcomes

NCT07097753 | Enrolling By Invitation DMC

• 1 other identifier: 20250529075134604
• Study Type: observational
• Target: 144
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a retrospective, single-center, pre-post controlled clinical study. Patients (n=48) who underwent the MIPPED-C surgical procedure after January 1, 2019 were designated as the treatment group. Patients who were admitted to the hospital from January 1, 2014 to December 31, 2018 and underwent traditional open surgery were retrospectively evaluated by surgeons, radiologists, and interventionalists, and then matched for propensity score with a 1:2 ratio. 96 patients who underwent traditional open surgery were selected as the control group. The treatment group underwent the MIPPED-C surgery, while the control group underwent the traditional open necrotic tissue debridement procedure. The differences in inflammatory indicators, SIRS response, immune indicators, organ function indicators, and imaging changes of the two groups of patients at the time of admission, before the operation, and after the operation were retrospectively collected. The survival status, postoperative complications, re-intervention status, hospital stay, ICU stay, and hospitalization costs of the two groups of patients after the operation were also collected.

Conditions

Acute Pancreatitis (AP); Acute Pancreatitis With Infected Necrosis

Outcome Measures

Primary Outcomes (1)

• all-cause mortality

  Half a year after the surgery

Study Arms (2)

Open surgical debridement of necrotic tissue

Minimally Invasive Partitioned Pancreatic Debridement and Enhanced Cross-Drainage

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who underwent traditional pancreatic debridement surgery and MIPPED-C IPN at Ruijin Hospital, affiliated to Shanghai Jiao Tong University School of Medicine from January 1, 2014 to December 31, 2023

Sponsors & Collaborators

• Ruijin Hospital: lead

Study Sites (1)

Emergency Department of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, China

Location

MeSH Terms

Conditions

Pancreatitis

Condition Hierarchy (Ancestors)

Pancreatic Diseases; Digestive System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 24, 2025
• First Posted: July 31, 2025
• Study Start: June 1, 2025
• Primary Completion: December 1, 2025
• Study Completion (Estimated): June 1, 2026
• Last Updated: July 31, 2025

Record last verified: 2025-05

Locations

CN (1)