Effects of Inspiratory Muscle Exercise on Health
Acute Effects of Intermittent Inspiratory Muscle Training on Blood Glucose and Vascular Function Responses
1 other identifier
interventional
48
0 countries
N/A
Brief Summary
The purpose of this study is to investigate whether inspiratory muscle training has an immediate effect on energy expenditure, heart rate, blood glucose, blood pressure, and arterial stiffness in healthy adults, obese adults, and adults with type 2 diabetes.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Mar 2026
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 24, 2025
CompletedFirst Posted
Study publicly available on registry
July 31, 2025
CompletedStudy Start
First participant enrolled
March 1, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
August 1, 2027
February 6, 2026
February 1, 2026
1.4 years
July 24, 2025
February 4, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Blood glycaemic responses
Changes in blood glycaemic responses between trials
0 (baseline), 30, 60, 120, and 210 minutes during the 210-minute trial
Pulse wave velocity (PWV)
Changes in pulse wave velocity between trials
0 (baseline), 30, 60, 90, 150, and 210 minutes during the 210-minute trial
Secondary Outcomes (4)
Energy expenditure
First 90 minutes during the 210-minute trial
Heart Rate Variability (HRV)
In a regular patterns during the 210-minute trial
Visual analogue scale (VAS)
Every 30 minutes during the 210-minute trial
Perceived stress scale (PSS)
Every 30 minutes during the 210-minute trial
Study Arms (2)
Eupnea
EXPERIMENTALParticipants will breathe normally.
Inspiratory muscle training
EXPERIMENTALIntermittent inspiratory muscle training (IMT) will be conducted throughout the trial
Interventions
Intermittent inspiratory muscle training (IIMT) will be conducted throughout the trial
Eligibility Criteria
You may qualify if:
- Healthy adults, obese adults and adults with type 2 diabetes
- Aged between 20 to 45 years
- Weight stable for more than 3 months (no change in weight +/- 3%)
- Non-smoker
- Non-highly trained athletic team members
- Normal lifestyle patterns
You may not qualify if:
- Personal history of/existing hypertension, respiratory infectious disease, cardiovascular disease, metabolic disease
- Taking medications that may influence lipid or carbohydrate metabolism or immune system function
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
July 24, 2025
First Posted
July 31, 2025
Study Start
March 1, 2026
Primary Completion (Estimated)
August 1, 2027
Study Completion (Estimated)
August 1, 2027
Last Updated
February 6, 2026
Record last verified: 2026-02