Perioperative Blood Transfusion and Increased One-year Mortality

NCT07094295 | Completed DMC

• 1 other identifier: PBTOM
• Study Type: observational
• Target: 97,443
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this retrospective observational study is to explore the association of perioperative blood transfusion with increased one-year mortality in patients undergoing surgeries. The main question it aims to answer perioperative blood transfusion is associated with increased one-year mortality across various surgical settings. We will retrospectively collect the clinical data (including one-year mortality) in patients with perioperative blood transfusion or not and analysis the association between perioperative blood transfusion and one-year mortality after surgery.

Conditions

Mortality, Perioperative Blood Transfusion, Propensity Score, Retrospective Study, Surgery

Outcome Measures

Primary Outcomes (1)

• one-year mortality after surgery

  one year after surgery

Study Arms (2)

PBT group

Patients in PBT group received red blood cell concentrate units during surgery and up to one month postoperatively.

Other: perioperative blood transfusion

No-PBT group

Patients in No-PBT group did not receive red blood cell concentrate units during surgery and up to one month postoperatively.

Interventions

perioperative blood transfusion OTHER

The PBT group received the red blood cell concentrate units during surgery and up to one month postoperatively.

PBT group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients who underwent surgery at Singapore General Hospital between 1 January 2012 and 31 October 2016

You may qualify if:

• ≥18 years
• Patients undergoing first-time cardiothoracic surgery, orthopedics, obstetrics and gynecology, general surgery, otolaryngology, hand surgery, neurosurgery, colorectal surgery, urology, plastic surgery, and oral and maxillofacial surgery were included.

You may not qualify if:

• Patients with missing values for the American Society of Anesthesiologists (ASA) physical status, revised cardiac risk index (RCRI), degree of preoperative anemia, kidney disease, or race were excluded.

Sponsors & Collaborators

• Changhai Hospital: lead

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 23, 2025
• First Posted: July 30, 2025
• Study Start: January 1, 2012
• Primary Completion: October 31, 2016
• Study Completion: October 31, 2016
• Last Updated: July 30, 2025

Record last verified: 2025-07