Effect of Delivery Method on Umbilical Cord Metabolomic Analysis

NCT07093957 | Completed

• 1 other identifier: CORD_omics
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Birth type is closely linked to fetal and maternal stress responses. In this study, we aimed to examine the effects of delivery method on the stress response in newborns at the metabolite level.

Conditions

Metabolomics; Cord Blood

Keywords

cord blood; metabolomics

Outcome Measures

Primary Outcomes (1)

• cord blood metabolomic analysis

  Cord blood samples will be analysed via LC/MS analysis

  From enrollment to birth. Cord Blood is taken during birth

Study Arms (2)

C/S

Babies delivered via C/S

Vaginal

Babies delivered vaginally

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The study population included pregnant women aged between 18 and 35 years who were regularly followed during their pregnancy and delivered at term. Women with a diagnosis of diabetes mellitus or hypertension either before or during pregnancy were excluded from the study. Additionally, pregnancies with multiple fetuses, non-elective cesarean sections, intrauterine growth restriction, or fetal congenital anomalies (or suspicion thereof) were not included. The study aimed to ensure a homogeneous and healthy sample to evaluate neonatal stress responses in relation to the mode of delivery.

You may qualify if:

• \) Female patient aged 18-35 2) Term pregnancy 3) Pregnant with follow-up

You may not qualify if:

• \) Having been diagnosed with diabetes mellitus before or during pregnancy 2) Having been diagnosed with hypertension before or during pregnancy 3) Non-singleton pregnancy 4) Non-elective C/S 5) Fetal intrauterine growth restriction 6) Mothers and their babies with a fetal birth anomaly or suspected birth anomaly will not be included in this study.

Sponsors & Collaborators

• Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital: lead

Study Sites (1)

Aksaray University

Aksaray, 68110, Turkey (Türkiye)

Location

Related Publications (3)

• Huang Y, Ni Y, Meng Y, Zeng X, He X, Zhang L, Zhang J. Integrated proteomics and metabolomics network analysis across different delivery modes in human pregnancy: a pilot study. BMC Pregnancy Childbirth. 2024 Dec 26;24(1):868. doi: 10.1186/s12884-024-07097-4.

  PMID: 39725908 BACKGROUND

• Shokry E, Marchioro L, Uhl O, Bermudez MG, Garcia-Santos JA, Segura MT, Campoy C, Koletzko B. Investigation of the impact of birth by cesarean section on fetal and maternal metabolism. Arch Gynecol Obstet. 2019 Sep;300(3):589-600. doi: 10.1007/s00404-019-05213-w. Epub 2019 Jun 14.

  PMID: 31201538 BACKGROUND

• Ross AB, Barman M, Hartvigsson O, Lundell AC, Savolainen O, Hesselmar B, Wold AE, Sandberg AS. Umbilical cord blood metabolome differs in relation to delivery mode, birth order and sex, maternal diet and possibly future allergy development in rural children. PLoS One. 2021 Jan 25;16(1):e0242978. doi: 10.1371/journal.pone.0242978. eCollection 2021.

  PMID: 33493154 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Cord blood metabolome analysis

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Week
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Anesthesiologist

Study Record Dates

• First Submitted: July 17, 2025
• First Posted: July 30, 2025
• Study Start: January 1, 2024
• Primary Completion: December 1, 2024
• Study Completion: July 1, 2025
• Last Updated: July 30, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)