Trials Sponsors Conditions Drugs Pricing

Conditions

Bone Marrow Stem Cells Exercise Training Post-menopausal Women Skeletal Muscle Recovery

Outcome Measures

Primary Outcomes (4)

Stro-1+ bone marrow stem cell area in skeletal muscle biopsies
Immunofluorescence staining will be used to semi-quantitatively analyze Stro-1+ BMSC presence in skeletal muscle of older women before, 0h and 24h after a moderate resistance exercise session.
from enrolment to the end of study at 8 weeks
Nestin+ neural stem cell area in skeletal muscle biopsies
Immunofluorescence staining will be used to semi-quantitatively analyze Nestin+ neural stem cell presence in skeletal muscle of older women before, 0h and 24h after a moderate resistance exercise session.
from enrolment to the end of study at 8 weeks
CD34+/CD31+ vascular stem cell area in skeletal muscle biopsies
Immunofluorescence staining will be used to semi-quantitatively analyzeCD34+/CD31+ vascular stem cell presence in skeletal muscle of older women before, 0h and 24h after a moderate resistance exercise session.
from enrolment to the end of study at 8 weeks

Study Arms (2)

exercise following Rg1 consumption

EXPERIMENTAL

1 hour following the consumption of the Rg1 supplement, participants performed exercise intervention before muscle biopsies were taken.

Dietary Supplement: exercise following Rg1 consumption

exercise only following placebo consumption

PLACEBO COMPARATOR

Crossover trial with placebo supplementation consumed before exercise

Dietary Supplement: Placebo

Interventions

exercise following Rg1 consumptionDietary supplement

The effect of Rg1 on exercised skeletal muscle in older women

exercise following Rg1 consumption

PlaceboDietary supplement

Resistance exercise performed 1 hour following placebo consumption

exercise only following placebo consumption

Eligibility Criteria

Age60 Years - 70 Years

Sexfemale

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

sedentary, able to cease medications and supplements for 48 h before and 24 h after exercise session, medically sound for lower body moderate resistance exercise

You may not qualify if:

Sponsors & Collaborators

University of Taipei
Otherlead

Study Sites (1)

University of Taipei

Taipei, Taipei, 11153, Taiwan

Related Publications (1)

Lee TXY, Wu J, Jean WH, Condello G, Alkhatib A, Hsieh CC, Hsieh YW, Huang CY, Kuo CH. Reduced stem cell aging in exercised human skeletal muscle is enhanced by ginsenoside Rg1. Aging (Albany NY). 2021 Jun 28;13(12):16567-16576. doi: 10.18632/aging.203176. Epub 2021 Jun 28.
PMID: 34181580BACKGROUND

Study Officials

Chia-hua Kuo, PhD
University of Taipei
PRINCIPAL INVESTIGATOR

Enrollment

11 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: not applicable
Allocation: RANDOMIZED
Masking: TRIPLE
Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose: BASIC SCIENCE
Intervention Model: CROSSOVER
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Professor

Study Record Dates

First Submitted

July 21, 2025

First Posted

July 30, 2025

Study Start

March 18, 2022

Actual (reported)

Stem Cell Recruitment in Exercised Skeletal Muscles of Older Women by Phytosteroid Rg1

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Outcome Measures

Primary Outcomes (4)

Study Arms (2)

exercise following Rg1 consumption

exercise only following placebo consumption

Interventions

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (1)

Study Officials

Enrollment

Study Design

Study Record Dates

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Outcome Measures

Primary Outcomes (4)

Study Arms (2)

exercise following Rg1 consumption

exercise only following placebo consumption

Interventions

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (1)

Study Officials

Enrollment

Study Design

Study Record Dates

Data Sharing

Source record

Locations