Mitigating Chronic Respiratory Disease Through the Lens of Multimorbidity

NCT07093021 | Not Yet Recruiting

• 2 other identifiers: 6981600 (UCL Worktribe)NIHR 303125
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 2

Brief Summary

The investigators aim to evaluate whether it is feasible for healthcare professionals to implement a case-finding tool to identify individuals at high risk for chronic respiratory diseases (CRDs) during routine care for non-communicable diseases (NCDs) in primary healthcare services in Brazil. The investigators will complete a cross-sectional observational study involving 20 healthcare professionals (physicians, physiotherapists, community health agents, and nurses) from five primary healthcare services who will apply the COLA-6 tool during routine NCD care. A total sample of 1,000 patients is expected. Qualitative interviews will be conducted with healthcare professionals to explore barriers and facilitators to implementing COLA-6 in clinical practice.

Conditions

Chronic Obstructive Pulmonary Disease (COPD); Asthma; Preserved Ratio Impaired Spirometry

Keywords

case-finding; chronic obstructive pulmonary disease; asthma; multi-morbidity

Outcome Measures

Primary Outcomes (1)

• Barriers and facilitators to implementing the COLA-6 case-finding tool.

  Barriers and facilitators to implementing the COLA-6 case-finding tool, assessed at qualitative interviews.

  At study completion: qualitative interviews will be completed after each HCP has completed 50 uses of COLA-6.

Eligibility Criteria

• Age: 30 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

1. HCPs providing NCD care in PHC services in Brazil. 2. Patients attending for NCD care in PHC services in Brazil.

You may qualify if:

• HCP: providing care to people with NCDs in PHC settings in Brazil. PATIENTS: attending for NCD care at a PHC setting in Brazil.

You may not qualify if:

• HCP: not received training to deliver COLA-6.
• PATIENTS:
• not provided informed consent
• clinically unstable in the past month
• current pregnancy
• active tuberculosis or being on treatment for tuberculosis
• cognitive impairment that would prevent understanding of the case-finding tool
• contra-indications to lung function testing.

Sponsors & Collaborators

• University College, London: lead
• Universidade Federal de Sao Carlos: collaborator

Study Sites (2)

Multiple primary care sites

São Carlos, São Paulo, Brazil

Location

Multiple primary care sites

São Paulo, São Paulo, Brazil

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Asthma

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Bronchial Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Officials

• John R Hurst, PhD FRCP

  University College London Hospitals

  PRINCIPAL INVESTIGATOR

• Renata G Mendes, DFisio

  Federal University of Sao Carlos (UFScar), Brasil

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Viviane Castello

CONTACT

(+5516) 99992 4777; vivianecastello@ufscar.br

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 18, 2025
• First Posted: July 30, 2025
• Study Start: August 1, 2025
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: July 30, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

BR (2)