Myocardial Infarction Safe Emergency Medicine Accompanying Study: Providing Reperfusion Therapy Within the Recommended Time Limits

NCT07092904 | Not Yet Recruiting

• 1 other identifier: 904338
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

The project is a prospective observational study with the aim of system improvement. It represents accompanying research in connection with the implementation of Safe Emergency Medicine , - an initiative under the auspices of the board of The North Norway Regional Health Authority and The Municipal Health Consortium that aims to provide faster and better treatment to patients with common, serious and time-critical conditions. The focus of the study is the decision-making process and implementation of treatment algorithms for all patients with acute ST-elevation myocardial infarction (STEMI) in the regional health trust's admission area. The data sources are 1) structured telephone interviews with providers and decision-makers and 2) electronic medical records (AMIS, DIPS, prehospital medical records from emergency departments, ambulance medical records). The analyses will form the basis for recommendations for improvements in procedures, training and organization.

Conditions

Infarction

Keywords

Acute myocardial infarction; Pharmacoinvasive; Reperfusion therapy; Emergency medicine; Prehospital thrombolysis; primary PCI

Outcome Measures

Primary Outcomes (1)

• Proportion of patients with acute ST elevation myocardial infarction who receive reperfusion therapy within the recommended time intervals.

  Internationally approved guidelines provide clear, evidence-based time interval recommendations for receiveing rapid reperfusion therapy, either by fibrinolytic medication or primary percutaneous coronary intervention. The primary endpoint adresses the extent of aim fulfillment.

  Inclusion will be performed during 6 months from September 1st 2025 - March 1st 2026. Each patient will be monitored for 1 month after enrollment (baseline). The interval from the diagnostic ECG recording to reperfusion therapy initiation is reported.

Study Arms (1)

Patients with acute ST elevation myocardial infarction in our region, all-comers

The patients are not subjected to any intervention for the study purpose.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients diagnosed with acute ST elevation myocardial infarction within the municipalities of Nordland, Troms and Finnmark.

You may qualify if:

• Patient with the diagnosis of acute ST elevation myocardial infarction located within the uptake area of the Northern Norway Regional Health Authority

You may not qualify if:

• Patient declines use of data

Sponsors & Collaborators

• University Hospital of North Norway: lead

Study Sites (1)

University hospital North Norway

Tromsø, Norway

Location

Related Publications (5)

• Uleberg B, Bonaa KH, Govatsmark RES, Olsen F, Jacobsen BK, Stensland E, Hauglann B, Vonen B, Forde OH. Exploring variation in timely reperfusion treatment in ST-segment elevation myocardial infarction in Norway: a national register-based cohort study. BMJ Open. 2024 Feb 17;14(2):e081301. doi: 10.1136/bmjopen-2023-081301.

  PMID: 38367969 BACKGROUND

• The Norwegian Registry for Myocardial Infarction. Annual Report for 2023. https://www.kvalitetsregistre.no/sites/default/files/2024-06/Årsrapport%202023_Norsk%20hjert

  BACKGROUND

• Hansen, AS (2021). Treatment and outcome for patients with ST-elevation myocardial infarction in Norway. Are there differences in the management and outcome of STEMI within Norway and compared to other Nordic countries? (Master's thesis, UiT Arctic University of Norway)

  BACKGROUND

• Bartnes K, Albrigtsen H, Iversen JM, Brovold H, Moller NH, Wembstad B, Arstad F, Kristensen AH, Cortis J, Olsen SJ, Nygaard SNS, Kindler SG, Moe O, Hansen C, Mannsverk JT. The Barriers to Rapid Reperfusion in Acute ST-Elevation Myocardial Infarction. Cardiol Ther. 2022 Dec;11(4):559-574. doi: 10.1007/s40119-022-00281-7. Epub 2022 Oct 6.

  PMID: 36203049 BACKGROUND

• Mannsverk J, Steigen T, Wang H, Tande PM, Dahle BM, Nedrejord ML, Hokland IO, Gilbert M. Trends in clinical outcomes and survival following prehospital thrombolytic therapy given by ambulance clinicians for ST-elevation myocardial infarction in rural sub-arctic Norway. Eur Heart J Acute Cardiovasc Care. 2019 Feb;8(1):8-14. doi: 10.1177/2048872617748550. Epub 2017 Dec 19.

  PMID: 29256635 BACKGROUND

MeSH Terms

Conditions

Infarction

Condition Hierarchy (Ancestors)

Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• Kristian Bartnes, PhD

  University hospital North Norway

  PRINCIPAL INVESTIGATOR

• Mads F Gilbert, PhD

  University hospital North Norway

  STUDY CHAIR

Central Study Contacts

Kristian Bartnes, PhD

CONTACT

+4797063364; kristian.bartnes@unn.no

Mads F Gilbert, PhD

CONTACT

+4790878740; mads.gilbert@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 8, 2025
• First Posted: July 30, 2025
• Study Start: September 1, 2025
• Primary Completion: March 1, 2026
• Study Completion: April 30, 2026
• Last Updated: July 30, 2025

Record last verified: 2025-06

Locations

NO (1)