Intensity-Dependent Effects of 4-week Transcranial Direct Current Stimulation on Motor Learning in Healthy Young Adults
1 other identifier
interventional
44
0 countries
N/A
Brief Summary
The goal of this clinical trial is to investigate the effects of different intensities of transcranial direct current stimulationover primary motor cortex on motor learning in healthy adults. The main question it aims to answer is: Which intensity of tDCS can best improve motor learning? Researchers will compare 1 mA, 2 mA, and 3 mA tDCS to sham tDCS to see which intensity of tDCS is most effective in improving the ability of motor learning. Participants will be randomly divided into four groups and receive 4 different intensities of tDCS(1 mA, 2 mA, 3 mA and sham tDCS),and will be blinded to the type of tDCS they received. We hypothesized that anodal tDCS at 2 mA would produce the most substantial improvement in motor learning.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Jul 2025
Shorter than P25 for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 20, 2025
CompletedStudy Start
First participant enrolled
July 20, 2025
CompletedFirst Posted
Study publicly available on registry
July 28, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 15, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2025
CompletedJuly 28, 2025
July 1, 2025
2 months
July 20, 2025
July 20, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Sequence Reaction Time Task
In this task, a white circle appears above one of four horizontally arranged white squares on the computer screen with black background. Participans were instructed to press the proper button on the response pad (buttons H, J, K, L) using the corresponding finger of the right hand (index finger for button H, middle finger for button J, ring finger for button K, and small finger for button L) when the white circle appeared at the left side, middle-left side, middle-right side, or right side of the computer screen, respectively. Each session consists of eight blocks, with each block comprising 120 trials.
Assessments will conducted before the intervention (Baseline), immediately after the first intervention (T1), at the end of 4 weeks (T2), and 1 week after the end of intervention (T3).
Study Arms (4)
1 mA transcranial direct current stimulation
EXPERIMENTALThe participants will receive 1 mA transcranial direct current stimulation (tDCS) over primary motor cortex(M1) intervention for a period of four weeks (10 sessions), but the participants will be blinded of what kind of intervention they are receiving.
2 mA transcranial direct current stimulation group
EXPERIMENTALThe participants will receive 2 mA transcranial direct current stimulation (tDCS) over primary motor cortex(M1) intervention for a period of four weeks (10 sessions), but the participants will be blinded of what kind of intervention they are receiving.
3 mA transcranial direct current stimulation group
EXPERIMENTALThe participants will receive 3 mA transcranial direct current stimulation (tDCS) over primary motor cortex(M1) intervention for a period of four weeks (10 sessions), but the participants will be blinded of what kind of intervention they are receiving.
sham transcranial direct current stimulation group
SHAM COMPARATORThe participants will receive sham transcranial direct current stimulation (tDCS) over primary motor cortex(M1) intervention for a period of four weeks (10 sessions), but the participants will be blinded of what kind of intervention they are receiving.
Interventions
The intervention will be conducted using a battery-powered stimulator (TCS-E2000, Shenzhen Yingchi Technology Co., Ltd) through a pair of saline-soaked sponge electrodes (5 cm × 7 cm).The stimulation intensity will be set at 3 mA. The stimulation will last for 20 minutes each time, with a 10 s fade-in period at the start and a 10-s fade-out period at the end of stimulation. The participants will receive intervention lasting for four weeks(10 sessions).The anodal electrode will be placed over the primary motor cortex (M1), and the reference electrode will be positioned at the center of the forehead.
The intervention will be conducted using a battery-powered stimulator (TCS-E2000, Shenzhen Yingchi Technology Co., Ltd) through a pair of saline-soaked sponge electrodes (5 cm × 7 cm).The stimulation intensity will be set at 2 mA. The stimulation will last for 20 minutes each time, with a 10 s fade-in period at the start and a 10-s fade-out period at the end of stimulation. The participants will receive intervention lasting for four weeks(10 sessions).The anodal electrode will be placed over the primary motor cortex (M1), and the reference electrode will be positioned at the center of the forehead.
The intervention will be conducted using a battery-powered stimulator (TCS-E2000, Shenzhen Yingchi Technology Co., Ltd) through a pair of saline-soaked sponge electrodes (5 cm × 7 cm).The stimulation intensity will be set at 1 mA. The stimulation will last for 20 minutes each time, with a 10 s fade-in period at the start and a 10-s fade-out period at the end of stimulation. The participants will receive intervention lasting for four weeks(10 sessions).The anodal electrode will be placed over the primary motor cortex (M1), and the reference electrode will be positioned at the center of the forehead.
The intervention will be conducted using a battery-powered stimulator (TCS-E2000, Shenzhen Yingchi Technology Co., Ltd) through a pair of saline-soaked sponge electrodes (5 cm × 7 cm).The intervention will last for 20 minutes each time, with a 10 s fade-in period at the start and a 10-s fade-out period at the end of stimulation，but there is not current in between. The participants will receive intervention lasting for four weeks(10 sessions).The anodal electrode will be placed over the primary motor cortex (M1), and the reference electrode will be positioned at the center of the forehead.
Eligibility Criteria
You may qualify if:
- age between 18 and 25 years; (2) normal or corrected-to-normal vision; (3) no history of pregnancy, cardiovascular disease, other physical impairments or illnesses, and no personal or family history of mental illness; (4) no implantation of any internal or external medical devices; and (5) right-handedness.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 20, 2025
First Posted
July 28, 2025
Study Start
July 20, 2025
Primary Completion
September 15, 2025
Study Completion
October 1, 2025
Last Updated
July 28, 2025
Record last verified: 2025-07