A Comparative Study Between Lumbar Epidural Analgesia Versus Local Infiltration Anesthesia Combined With Dexmedetomidine Intravenous Infusion in Endoscopic Lumbar Discectomy Surgeries: A Retrospective Study

NCT07088016 | Completed

• 1 other identifier: 6/02-2025
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to compare the effectiveness and patient satisfaction of local anesthesia combined with intravenous Dexmedetomidine versus epidural anesthesia in endoscopic lumbar discectomy surgeries

Conditions

Epidural Analgesics for Comparison

Keywords

epidural; dexmedetomidine; microscopic lumber discectomy

Outcome Measures

Primary Outcomes (1)

• we compare numerical rating pain score (NRS) between the two groups immediately at foraminal dilatation maneuver

  It refers to the common method used in healthcare where patients rate their pain on a scale from 0 to 10: 0 = No pain 10 = Worst pain imaginable.

  from January 2021 to January 2024

Secondary Outcomes (3)

• Heart rate (H.R)

  from January 2021 to January 2024

• Mean arterial blood pressure (MABP)

  from January 2021 to January 2024

• we compare Bromage scale in the two groups intraoperative during foraminal dilatation by the surgeon

  from January 2021 to January 2024

Study Arms (2)

dexmedetomidine group

loading of Dexmedetomidine was done at a dose of 1 mcg/ kg over 10 minutes followed by continuous infusion at a rate of 0.5 mcg/kg/hr , followed by infiltration of the skin with 2-3 ml of lidocaine hydrochloride 1 % first by the surgeon then an 18 -G needle will be introduced to anesthetize the trajectory with 8-10 ml lidocaine 1 %. After reaching the superior articular process, 2-3 ml of lidocaine 1 % was used to anesthetize the facet joint.

Epidural group

The epidural insertion point was 2 segments upper than the surgical procedure, 10 ml of Bupivacaine 0.25% was injected in the epidural space to adjust the sensory level. The epidural catheter will be removed after 2 hours from the end of the operation

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients are American Society of anesthesiologists' physical status (ASA) I to II aged 18 to 60 years of both sexes with clinical and radiological evidence of soft disc herniation in a single lumber segment.

You may qualify if:

• Patients American Society of anesthesiologists' physical status (ASA) I to II.
• Aged 18 to 60 years.
• Both sexes.
• Patients with clinical and radiological evidence of soft disc herniation in a single lumber segment.

You may not qualify if:

• Spinal malformation
• Recurrent lumber disc herniation (LDH)
• Multi segment LDH
• Patients younger than 18 years or older than 60 years
• Patients with hypersensitivity to one of the used drugs
• Patients suffering of coagulopathy
• Operation time more than 1 hour

Sponsors & Collaborators

• Ain Shams University: lead
• Egyptian Center for Research and Regenerative Medicine: collaborator

Study Sites (1)

International Medical Center

Cairo, Egypt

Location

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: July 9, 2025
• First Posted: July 28, 2025
• Study Start: January 1, 2021
• Primary Completion: January 1, 2024
• Study Completion: January 1, 2024
• Last Updated: July 28, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)