Midterm Follow up Outcomes of (SASJ) in Management of Morbid Obesity

NCT07087535 | Active Not Recruiting

• 1 other identifier: Soh-Med--25-6-9MS
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Obesity is a critical health problem associated with an increased risk of cardiovascular disease, diabetes, and cancers, affecting both the quality of life and life expectancy . The increasing prevalence of obesity and comorbid conditions requires effective treatment and prevention . Previous evidence has demonstrated that bariatric surgery is associated with greater and longer-term weight loss than non-surgical management Thus, in patients with a body mass index of ≥ 40 or ≥ 35 kg/m2 with co-morbidities, bariatric surgery is the most effective treatment option that not only promotes weight loss but also improves comorbid conditions . However, like any surgical procedure, several complications can occur . The development of nutritional deficiencies is a complication which may be life-threatening; therefore, bariatric surgery requires careful consideration . The most frequently performed surgery for obesity worldwide is the laparoscopic sleeve gastrectomy (LSG), the Roux-en-Y gastric bypass (RYGB), and more recently, the one anastomosis gastric bypass (OAGB) . One newly developed weight loss procedure, the single sleeve ileal anastomosis bypass (SASI), has been developed as a modification to Santoro's operation (sleeve gastrectomy with transit bipartition SG + TB) . Since no duodenal division or manual anastomosis is required, the procedure allows easy endoscopic access to the duodenum . noted that SASI has the following advantages over other bariatric procedures: SASI has a shorter operative time compared to other procedures; 2) easy access to the duodenum and biliary tree endoscopically; 3) SASI does not divide the duodenum, thus eliminating the possibility of duodenal stump leakage, a serious complication with an incidence range between; 4) the tension on the anastomosis lower than other techniques; 5) there are no blind loops, excluded segments, or foreign bodies; 6) SASI is completely reversible . Single anastomosis sleeve jejunal (SASJ) bypass, which is the focus of this study, is a modification of SASI using a shorter biliopancreatic limb length compared to SASI to prevent long-term nutritional complications . The SASJ bypass appears to be safer than the SASI procedure in patients with excessive weight loss and nutritional deficiencies and is simpler due to its improved surgical ergonomics . Aim of the Work This study aims to evaluate the three-year outcomes of SASJ bypass as a primary bariatric procedure in a tertiary bariatric center for weight loss, comorbidity resolution, and both early and late complications.

Conditions

Morbid Obesity Requiring Bariatric Surgery

Keywords

obesity

Outcome Measures

Primary Outcomes (1)

• weight loss outcomes

  * Percentage of excess weight loss * Percentage of total weight loss

  2 years

Secondary Outcomes (1)

• comorbidities readmission reoperation

  2 years

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Sohag University Hospitals

You may qualify if:

• Age from 18 to 65 years old.
• Both sexes.
• Body mass index (BMI) \> 35 with comorbidities or BMI \> 40 with or without comorbidities.
• Primary bariatric procedure.
• Follow up period 2 years or more after SASJ.

You may not qualify if:

• Follow up period less than 2 years.
• Previous laparoscopic metabolic surgery
• Patients with huge anterior abdominal wall hernias.
• Cirrhotic patients.
• Pregnant or lactating females.
• Unfit patients for anesthesia.
• patients requiring revisional bariatric surgery.
• Patients with any contraindications to laparoscopic surgery.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag Hospital University

Sohag, 82515, Egypt

Location

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Target Duration: 2 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident

Study Record Dates

• First Submitted: July 10, 2025
• First Posted: July 28, 2025
• Study Start: June 1, 2019
• Primary Completion: June 30, 2023
• Study Completion: December 1, 2025
• Last Updated: July 28, 2025

Record last verified: 2025-07

Locations

EG (1)