Independent Effects of Visceral Adipose Volume and Density on Patient Survival in Peritoneal Dialysis

NCT07086430 | Completed

• 1 other identifier: LY2025-017-B
• Study Type: observational
• Target: 358
• Locations: 0 countries
• Sites: N/A

Brief Summary

It was VAT volume predict patient outcome, while VAT density predicted baseline membrane function in PD patients and reflected peritoneal vascular density and local inflammation status.

Conditions

Uremia; End Stage Renal Disease on Dialysis

Keywords

peritoneal dialysis; fat attenuation index on CT

Outcome Measures

Primary Outcomes (1)

• To evaluate the association between peritoneal membrane solute transfer rate and abdominal visceral adipose tissue density measured on CT

  from the baseline, 4 weeks before PD catheter insert surgery until patients quit PD or follow up up to 48 months

Study Arms (1)

derivation cohort; validation cohort

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study included peritoneal dialysis patients follow up in our center who had an abdominal CT scan within 2 weeks before PD catheter incubation. Those with acute inflammation according to clinical signs, lab results or abdominal CT scan were excluded from the cohort. In early years, abdominal CT scan was done if the patient reported history of abdominal abnormalities, such as history of cholelithiasis. Since 2020 it became a routine check before PD catheter incubation in our center. Those with cholelithiasis or hernia were suggested to had the preventive operation at the time of PD catheter incubation under general anesthesia. The patients started PD within 4 weeks after catheter incubation. A validation cohort was from a satellite center of the hospital. The inclusion criteria were same as the derivation cohort.

You may qualify if:

• The study included peritoneal dialysis patients follow up in our center who had an abdominal CT scan within 2 weeks before PD catheter incubation.

You may not qualify if:

• Those with acute inflammation according to clinical signs, lab results or abdominal CT scan were excluded from the cohort.

Sponsors & Collaborators

• RenJi Hospital: lead

MeSH Terms

Conditions

Uremia

Condition Hierarchy (Ancestors)

Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: July 14, 2025
• First Posted: July 25, 2025
• Study Start: July 21, 2015
• Primary Completion: July 11, 2023
• Study Completion: May 1, 2025
• Last Updated: July 25, 2025

Record last verified: 2025-04