AB-1005 Long-Term Follow-up Study
Long-Term Safety and Efficacy Follow-up of AB-1005 Gene Transfer Study Participants With Parkinson's Disease or Multiple System Atrophy
1 other identifier
observational
132
1 country
2
Brief Summary
This is an observational, long term, follow-up study for participants with Parkinson's disease (PD) or Multiple System Atrophy-Parkinsonian subtype (MSA-P) who participated in prior interventional studies with AB-1005. It is intended to better understand the long-term safety of AB-1005, how well tolerated it is and how long lasting the effects are.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Sep 2025
Longer than P75 for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 9, 2025
CompletedFirst Posted
Study publicly available on registry
July 23, 2025
CompletedStudy Start
First participant enrolled
September 4, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2037
ExpectedStudy Completion
Last participant's last visit for all outcomes
March 30, 2038
October 2, 2025
September 1, 2025
12.1 years
June 9, 2025
September 29, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Long term safety and tolerability
Measure of the occurrence of serious and non-serious adverse events
Up to 10 years post surgery
Study Arms (2)
Participants with PD
Participants with MSA-P
Interventions
This is an observational study in which safety laboratories and non-invasive routine clinical assessments are conducted to gauge long term safety and efficacy.
Eligibility Criteria
Participants who have participated in interventional studies of AB-1005.
You may qualify if:
- PD and MSA-P participants that are or were enrolled in an interventional AB-1005 study and provide informed consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- AskBio Inclead
Study Sites (2)
University of California San Francisco
San Francisco, California, 94143, United States
Ohio State University
Columbus, Ohio, 43210, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 9, 2025
First Posted
July 23, 2025
Study Start
September 4, 2025
Primary Completion (Estimated)
September 30, 2037
Study Completion (Estimated)
March 30, 2038
Last Updated
October 2, 2025
Record last verified: 2025-09
Data Sharing
- IPD Sharing
- Will not share