Role of Early API in Accurately Differentiating Hepatocellular Carcinoma From Dysplastic Nodules in Cirrhotic Patients

NCT07080372 | Active Not Recruiting DMC

• 1 other identifier: MSAHSW/Batch-Fall23/926
• Study Type: observational
• Target: 73
• Locations: 1 country
• Sites: 1

Brief Summary

Liver cirrhosis is a common consequence of chronic liver disease, resulting from sustained hepatic injury due to various etiologies. Cirrhosis predisposes individuals to the development of hepatocellular carcinoma (HCC), the most prevalent primary malignancy of the liver. Among cirrhotic patients, distinguishing between hepatocellular carcinoma and dysplastic nodules is crucial for timely diagnosis, treatment planning, and prognostic assessment.

Conditions

Dysplastic Nodule

Outcome Measures

Primary Outcomes (1)

• self administered proforma form

  A clinical history form is a structured document used to gather comprehensive information about a patient's medical background and current health status. It typically includes sections for identifying patient demographics, past medical history, family history, social history, medications, allergies, and a detailed account of the current illness or complaint.

  12 Months

Interventions

assesment DIAGNOSTIC_TEST

This study aims to assess the role of early arterial phase in detecting and differentiating hepatocellular carcinoma from dysplastic nodules in chronic liver disease patients.

Eligibility Criteria

• Age: 5 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Aim of the study: This study aims to assess the role of early arterial phase in detecting and differentiating hepatocellular carcinoma from dysplastic nodules in chronic liver disease patients

You may qualify if:

• Patients with abnormal LFTs
• Liver lesions of various sizes
• Patients with chronic liver disease
• Individuals undergoing routine liver screening
• Willing participants who consent to the study

You may not qualify if:

• Children less than 5years
• Patients who are allergic or have a history of allergy to contrast media
• Patients with deranged renal function tests
• Pregnant women

Sponsors & Collaborators

• Superior University: lead

Study Sites (1)

Lahore General Hospital

Lahore, Pakistan

Location

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: June 28, 2025
• First Posted: July 23, 2025
• Study Start: March 17, 2025
• Primary Completion: September 1, 2025
• Study Completion: February 28, 2026
• Last Updated: July 23, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)