Research on the Evolution, Geometry, and Alterations of the Periorbital Region Based on Age and Deformations

NCT07080320 | Active Not Recruiting

• 1 other identifier: PI2025_843_0101
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The periorbital region of the face is a critical area affected by aging. Motion Capture (MoCap) allows the precise measurement of the mechanical properties of skin in this region. This study will validate MoCap as a tool for quantifying these properties, comparing it to traditional reference tools, and exploring how these properties evolve with age and external treatments. It will also assess MoCap's ability to detect the effects of various treatments such as tightening products and massages. Ultimately, this research will provide a deeper understanding of skin dynamics in the periorbital region and offer insights into both medical and cosmetic applications.

Conditions

Facial Skin; Motion Capture; Aging; Periorbital Region; Skin Movement; Vertical Jump

Keywords

Facial skin; motion capture; aging; periorbital region; mechanical; skin movement; vertical jump

Outcome Measures

Primary Outcomes (1)

• maximum displacement (in millimeters) of each marker placed on the face

  maximum displacement (in millimeters) of each marker placed on the face during standardized movements of the periorbital region

  day 1

Secondary Outcomes (6)

• Coefficient of variation of the maximum displacement amplitudes measured during repeated tests for the same movement.

  day 1

• The correlation coefficient between dynamic MoCap measurements and static measurements obtained from reference tools.

  day 1

• The difference in the mean maximum displacement amplitudes (in millimeters) between different age groups

  day 1

• The difference in the mean maximum displacement amplitudes (in millimeters) before and after performing a periorbital massage

  day 1

• The maximum mean displacement amplitudes (in millimeters) during a mechanical solicitation (a standardized vertical jump).

  day 1

Study Arms (2)

subjects aged 18-33 years

EXPERIMENTAL

Device: MoCap

subjects aged 50-65 years

EXPERIMENTAL

Device: MoCap

Interventions

MoCap DEVICE

For each subject, the displacement of markers, the deformation of regions between markers, and the evolution of angles formed by the markers during facial expressions and vertical movements will be analyzed with MoCap. These will be compared between the two age groups (18-33 years vs. 50-65 years) using a MANOVA model. The reference values for marker displacement will be defined by the interval between the 2.5% and 97.5% percentiles of the values for each marker. If the distribution is Gaussian, the percentiles will be derived from the standard normal distribution; otherwise, the non-parametric method will be used. The intervention will be Interventions : * Recruitment of healthy and pathological subjects. * Full-face and macro images of the periorbital region * Measurement of periorbital skin properties using MoCap and standard reference tools. * Application of a tightening product (aloe vera) and periorbital massage. * Measurement of skin response to a vertical jump.

subjects aged 18-33 years; subjects aged 50-65 years

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Female participants
• Caucasian, Fitzpatrick skin types I-III
• BMI between 18.5 and 27, healthy participants
• Aged 18 to 65 years (inclusive)
• Not under guardianship or curatorship
• Informed written consent
• Social security affiliation
• Non-smokers for at least 5 years
• No excessive UV exposure (artificial or natural) in the last 3 weeks prior to the study or during the study

You may not qualify if:

• Severe skin disorders preventing the application of electrodes or photo-reflective markers
• Neurovascular history affecting the face
• Ongoing treatments influencing facial tissues (e.g., corticosteroids)
• Current sleep disorders
• Psychiatric conditions or social interaction impairments
• Inner ear or balance disorders
• Osteoporosis, recent fractures, or fragile bone conditions
• Pregnant or breastfeeding women
• Under guardianship, curatorship, or legal protection

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead

Study Sites (1)

CHRU Amiens

Amiens, 80480, France

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 15, 2025
• First Posted: July 23, 2025
• Study Start: September 20, 2025
• Primary Completion (Estimated): August 1, 2027
• Study Completion (Estimated): September 1, 2027
• Last Updated: February 5, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)