Association Between Ambient Temperature and Myocardial Injury After Noncardiac Surgery in Adults

NCT07079891 | Completed DMC

• 1 other identifier: 20256030
• Study Type: observational
• Target: 143,095
• Locations: 0 countries
• Sites: N/A

Brief Summary

This single-center retrospective cohort study enrolled patients aged ≥18 years who underwent noncardiac surgery between January 2014 and December 2023. The exposure variable was the 7-day average preoperative ambient temperature in Beijing. Univariate and multivariate logistic regression models were used to evaluate the association between temperature and MINS. Inverse probability of treatment weighting (IPTW) analysis was performed to enhance the robustness of the findings. Subgroup analyses were performed across predefined clinical strata.

Conditions

MINS

Outcome Measures

Primary Outcomes (1)

• incidence of MINS

  POSTOPERATIVE 30 DAYS

Study Arms (4)

moderate heat (22.8℃-29.2℃)

Other: MINS

extreme heat (≥29.2℃)

Other: MINS

extreme cold (≤-3.5℃)

Other: MINS

moderate cold (-3.5℃-22.8℃)

Other: MINS

Interventions

MINS OTHER

MINS

extreme cold (≤-3.5℃); extreme heat (≥29.2℃); moderate cold (-3.5℃-22.8℃); moderate heat (22.8℃-29.2℃)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This retrospective single-center cohort study included 143,095 adult (≥18 years) patients who underwent noncardiac surgery under general anesthesia between January 2014 and December 2023. The exclusion criteria were as follows: (1) American Society of Anesthesiologists (ASA) classification V; (2) outpatient, hysteroscopic, or body surface surgeries; (3) surgery duration ≤30 min; (4) absence of postoperative high-sensitivity troponin T (hs-TnT) testing within 30 days; and (5) incomplete clinical data (≥20% missing data).

You may qualify if:

• ≥18 years
• underwent noncardiac surgery under general anesthesia

You may not qualify if:

• American Society of Anesthesiologists (ASA) classification V;
• outpatient, hysteroscopic, or body surface surgeries
• surgery duration ≤30 min
• absence of postoperative high-sensitivity troponin T (hs-TnT) testing within 30 days
• incomplete clinical data (≥20% missing data)

Sponsors & Collaborators

• Hao Li: lead

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: June 30, 2025
• First Posted: July 23, 2025
• Study Start: January 1, 2013
• Primary Completion: December 31, 2023
• Study Completion: December 31, 2023
• Last Updated: July 23, 2025

Record last verified: 2025-07