Micellar Water and the Skin Barrier: Comparing Rinsing vs. Non-Rinsing Application

NCT07079371 | Active Not Recruiting

• 1 other identifier: 2181-198-03-04-25-0065
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to assess how micellar water affects the skin barrier in healthy adult volunteers. The main questions it aims to answer are:

• Does leaving micellar water on the skin affect skin barrier function differently than rinsing it off?
• Are there measurable differences in transepidermal water loss (TEWL), skin hydration, and erythema between the two application methods? Researchers will compare the effects of micellar water left on the skin versus rinsed off after application. Participants will:
• Be randomly assigned to one of two groups
• Apply micellar water to their forehead once daily for 21 days
• Either leave the micellar water on or rinse it off, depending on their group
• Undergo non-invasive measurements of TEWL, skin hydration, and erythema before and after the intervention

Conditions

Effects of Micellar Water Application on Skin Barrier Integrity, Hydration, and Erythema in Healthy Skin

Outcome Measures

Primary Outcomes (3)

• Change in TransEpidermal Water Loss (TEWL)

  Measurement of transepidermal water loss on the forehead to assess skin barrier function.

  Four measurements total: one at baseline (before application), and one at the start of each week during the 3-week intervention (Days 0, 7, 14, and 21).

• Change in Skin Hydration

  Measurement of skin hydration levels on the forehead before and after micellar water application.

  Four measurements total: one at baseline (before application), and one at the start of each week during the 3-week intervention (Days 0, 7, 14, and 21).

• Change in Erythema

  Assessment of skin redness (erythema) on the forehead before and after of micellar water application.

  Four measurements total: one at baseline (before application), and one at the start of each week during the 3-week intervention (Days 0, 7, 14, and 21).

Study Arms (2)

Micellar Water Application Without Rinsing

EXPERIMENTAL

Participants apply micellar water to the forehead once daily and leave it on the skin without rinsing. Skin barrier function is assessed before and after 21 days of application.

Procedure: Micellar Water Application (No Rinse)

Micellar Water Application With Rinsing

EXPERIMENTAL

Participants apply micellar water to the forehead once daily and rinse it off after application. Skin barrier function is assessed before and after 21 days of application.

Procedure: Micellar Water Application (With Rinse)

Interventions

Micellar Water Application (No Rinse) PROCEDURE

Participants apply micellar water to the forehead once daily and leave it on the skin without rinsing for 21 days.

Micellar Water Application Without Rinsing

Micellar Water Application (With Rinse) PROCEDURE

Participants apply micellar water to the forehead once daily and rinse it off after application for 21 days.

Micellar Water Application With Rinsing

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy adult volunteers aged 18 years and older. Willingness and ability to comply with study procedures. Signed informed consent indicating understanding of study participation, rights, and potential risks and benefits. No current skin diseases or conditions at the test site. Ability to attend all study visits and follow instructions

Sponsors & Collaborators

• University of Split, School of Medicine: lead

Study Sites (1)

Univerity of Split School of Medicine

Split, 21000, Croatia

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 14, 2025
• First Posted: July 23, 2025
• Study Start: June 18, 2025
• Primary Completion: January 1, 2026
• Study Completion: January 1, 2026
• Last Updated: July 23, 2025

Record last verified: 2025-06

Locations

CR (1)