Correlation Between Serum Copper and Cardiac Enzymes in Acute Myocardial Infarction

NCT07076758 | Completed

• 1 other identifier: Soh-Med-25-5-7PD
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate the correlation between serum copper levels and cardiac enzymes in patients with acute myocardial infarction (AMI).

Conditions

Serum Copper; Cardiac Enzymes; Acute Myocardial Infarction

Outcome Measures

Primary Outcomes (1)

• Serum copper level

  Serum copper level will be recorded.

  Immediately after echocardiography (Up to 1 hour)

Secondary Outcomes (4)

• Correlation between copper zinc and cardiac enzyme

  Immediately after echocardiography (Up to 1 hour)

• Creatine kinase

  Immediately after echocardiography (Up to 1 hour)

• MB fraction of creatine kinase

  Immediately after echocardiography (Up to 1 hour)

• Cardiac troponin T

  Immediately after echocardiography (Up to 1 hour)

Study Arms (2)

Group I

Patients with acute myocardial infarction.

Other: Transthoracic echocardiography

Group II

Healthy control individuals as a control group.

Other: Transthoracic echocardiography

Interventions

Transthoracic echocardiography OTHER

Transthoracic echocardiography will be done for all patients during their cardiac care unit stay including two-dimensional and color Doppler echocardiography studies. It will be performed in the left lateral position using the parasternal and apical transducer positions. All studies will be technically adequate for scoring endocardial regional wall motion. The following views will be obtained: long-axis parasternal, short-axis parasternal, apical four chamber, apical two-chamber and apical five-chamber views. All the measurements taken will be according to the criteria of the American Society of Echocardiography

Group I; Group II

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This case-control study will be conducted at Sohag University Hospitals after approval from the institutional ethical committee.

You may qualify if:

• Age ≥18 years old.
• Both sexes.
• Patients with acute myocardial infarction (AMI). AMI are defined as patients complaining of typical continuous chest pain for more than 30 min: ST-segment elevation of more than 0.1 mV in two or more successive leads or ST-segment depression of more than 0.1 mV in two or more successive leads monitored by a standard 12-lead ECG and rise of either creatine kinase (CK) or MB fraction of creatine kinase (CKMB) to greater than twice the normal level or elevation of troponin I \[cardiac troponin T (cTnT)\] more than or equal to 0.1 ng/ml

You may not qualify if:

• Patients with insufficient clinical information.
• Passed time MI (if patients presented with symptoms that lasted \>24 h).
• Cardiogenic shock.
• Chronic kidney disease.
• Chronic liver cell failure.
• Significant valvular heart disease.
• Hematological disease.
• Malignancy.
• Severe liver or renal disease.
• Systemic inflammatory disease.
• Active infection.
• Autoimmune disease.
• Patients on steroids whatever the cause is.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag University

Sohag, 82511, Egypt

Location

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Cardiovascular, Faculty of Medicine, Sohag University, Sohag, Egypt.

Study Record Dates

• First Submitted: July 12, 2025
• First Posted: July 22, 2025
• Study Start: January 1, 2025
• Primary Completion: July 8, 2025
• Study Completion: July 8, 2025
• Last Updated: July 22, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)