Intraoperative Heart Rate Thresholds and Postoperative Mortality

NCT07075744 | Completed

• 1 other identifier: AMC [2023-0611]
• Study Type: observational
• Target: 139,149
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective observational study investigates the association between intraoperative heart rate and 30-day postoperative mortality among patients undergoing non-cardiac surgery. The findings suggest that heart rate abnormalities during surgery may significantly affect short-term postoperative outcomes.

Conditions

HEART RATE

Keywords

Heart rate; Intraoperative; Tachycardia; Bradycardia; Mortality

Outcome Measures

Primary Outcomes (1)

• All-cause mortality within 30 days after non-cardiac surgery

  The primary outcome is defined as death from any cause occurring within 30 days after the date of surgery. Mortality data were collected from institutional electronic medical records and verified through discharge and follow-up records. The association between intraoperative heart rate metrics and postoperative mortality was retrospectively analyzed.

  30 days after the date of surgery

Study Arms (1)

Non-cardiac Surgery Cohort

This cohort includes adult patients who underwent non-cardiac surgery under general or regional anesthesia. The study retrospectively examined intraoperative heart rate patterns and their association with postoperative 30-day mortality. No intervention was applied as this is an observational study.

Other: Intraoperative Heart Rate Monitoring

Interventions

Intraoperative Heart Rate Monitoring OTHER

This is a non-interventional observational analysis of intraoperative heart rate metrics, including minimum, maximum, average, and time-weighted average heart rate recorded during non-cardiac surgery. The study also includes duration-based metrics such as time spent below or above specific heart rate thresholds. These variables were retrospectively analyzed for their association with 30-day postoperative mortality. No clinical intervention or treatment was administered as part of this study.

Non-cardiac Surgery Cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients (aged 18 years or older) who underwent non-cardiac surgery under general or regional anesthesia at a single tertiary medical center. Only the first surgery after admission was included for patients who underwent multiple procedures. Patients undergoing cardiac-related procedures, pediatric or obstetric cases, cadaveric surgeries, or those with incomplete vital signs or laboratory data were excluded.

You may qualify if:

• Patients who underwent non-cardiac surgery at our medical center between March 2019 and February 2023
• Age ≥ 18 years
• Availability of complete laboratory data and perioperative vital signs
• Only the first surgery performed after hospital admission was included for patients with multiple

You may not qualify if:

• Cardiac-related surgical procedures
• Pregnancy at the time of surgery
• Age \< 18 years
• Surgeries lasting less than 30 minutes
• Cadaveric procedures
• Missing or incomplete laboratory values or vital sign data

Sponsors & Collaborators

• Asan Medical Center: lead

Study Sites (1)

Asan Medical Center

Seoul, Songpa-gu, 05505, South Korea

Location

MeSH Terms

Conditions

Tachycardia; Bradycardia

Condition Hierarchy (Ancestors)

Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Cardiac Conduction System Disease; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: July 11, 2025
• First Posted: July 20, 2025
• Study Start: August 30, 2023
• Primary Completion: December 31, 2024
• Study Completion: January 20, 2025
• Last Updated: July 20, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)