EEG During Gastroscopy and/or Colonoscopy

NCT07073274 | Completed

• 1 other identifier: HUB2025185
• Study Type: interventional
• Target: 149
• Locations: 1 country
• Sites: 1

Brief Summary

During anesthesia, EEG shows specific and significant changes according to the depth of anesthesia and the drugs used. Endoscopic procedures like gastroscopies or colonoscopies are usually done on an outpatient basis using essentially propofol for sedation or anesthesia. Preliminary reports have shown that the depth of anesthesia during these procedures may be very deep resulting even in a burst suppression pattern on the EEG. In this study, frontal EEG will be recorded continuously using a Root - Sedline device (Masimo, US). Anesthesiologists will be free to use the medications and dosage they judge appropriate. The attending anesthesiologist will be blinded to the EEG. Medications and dosages will be recorded, as well as processed EEG data from the Sedline and the raw EEG. Primary outcome is the % of time spend in specific range of patient state index (PSI 0-10; 10-20; 20-30; 30-40; 40-50; 5-60; 60-70; 70-80; 80-90; 90-100) as well as the % of time spent in burst suppression.

Conditions

Endoscopy of Stomach (Procedure); Colonoscopy (Procedure); Continuous Processed Electroencephalogram (Procedure)

Keywords

Anesthesia; EEG; Burst suppression; gastroscopy; colonoscopy

Outcome Measures

Primary Outcomes (2)

• Burst suppression

  Percentage of time spent in burst suppression

  90 min

• PSI

  Percentage of time spent in each PSI range

  90 min

Study Arms (1)

EEG monitoring

OTHER

Continuous EEG monitoring

Diagnostic Test: EEG analysis

Interventions

EEG analysis DIAGNOSTIC_TEST

All patients will have a continous recording of their EEG during anesthesia

EEG monitoring

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients undergoing gastroscopy and or colonoscopy in a outpatient setting under sedation or general anesthesia

You may not qualify if:

• Patients \< 18 years
• altered renal function, Glomerular filtration rate \< 50 mL/min/m2
• altered hepatic tests, \> 1.5 \* upper normal limit
• Any form of hepatic cirrhosis
• Presence of oesophageal varices
• Any neurological pathology rendering EEG analysis non reliable

Sponsors & Collaborators

• Erasme University Hospital: lead

Study Sites (1)

H.U.B _ Hôpital Erasme

Brussels, 1070, Belgium

Location

Related Publications (1)

• John ER, Prichep LS, Kox W, Valdes-Sosa P, Bosch-Bayard J, Aubert E, Tom M, di Michele F, Gugino LD. Invariant reversible QEEG effects of anesthetics. Conscious Cogn. 2001 Jun;10(2):165-83. doi: 10.1006/ccog.2001.0507.

  PMID: 11414713 BACKGROUND

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 9, 2025
• First Posted: July 18, 2025
• Study Start: July 25, 2025
• Primary Completion: February 15, 2026
• Study Completion: February 28, 2026
• Last Updated: March 18, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)