Substance Use in Assault-Injured Young Adults

NCT07070414 | Not Yet Recruiting

• 2 other identifiers: 20000404901R34DA061051-01A1
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to improve a short motivational conversation to better help young adults who were injured in assaults and also use alcohol or cannabis. Researchers will gather both interview and survey data from young adults who came to the emergency department after an assault and currently use alcohol or cannabis. Guided by a theory about risky behaviors, the study will focus on how confident young people feel about making changes to their alcohol and cannabis use, and how their friends and family influence their alcohol and cannabis use and involvement in injuries from assault. The team will follow a step-by-step process used by the NIH to adapt and test the improved motivational conversation in the emergency department.

Conditions

Alcohol Misuse; Cannabis Misuse

Keywords

alcohol misuse; cannabis misuse

Outcome Measures

Primary Outcomes (4)

• Feasibility assessed by recruitment

  Recruitment measured as the percentage of those invited/those who enrolled

  Day 0 and 30

• Feasibility assessed by randomization

  Recruitment measured as the percentage of screened eligible participants who enroll/those who receive either intervention or control arm

  Day 0 and 30

• Feasibility assessed by retention

  Recruitment measured as the percentage of those enrolled who have received either intervention or control arm/ participants who have completed all 30-day follow up assessments

  Day 0 and 30

• Acceptability assessed by Acceptability of Intervention Measure (AIM)

  Acceptability of the intervention will be assessed using the Acceptability of Intervention Measure (AIM). It has 4-items scored on a 5-point Likert scale summed to achieve a total score. Total score range of 0-20. Higher scores indicate more acceptability.

  Day 0

Study Arms (2)

Brief Negotiation Interview intervention (BNI) (adapted)

EXPERIMENTAL

Participants randomized to the intervention arm will receive a brief motivational interview designed to increase motivation to reduce alcohol and/or cannabis use and engagement in treatment referral at 30-days. A referral includes a contact number to addiction treatment (primary care and/or specialty addiction care consistent with diagnostic criteria) and injury prevention services at the Yale Hospital Violence Intervention Program.

Behavioral: Brief Negotiation Interview intervention (BNI) (adapted)

Control Group

NO INTERVENTION

Control group will receive contact referrals only. A referral includes a contact number to addiction treatment (primary care and/or specialty addiction care consistent with diagnostic criteria) and injury prevention services at the Yale Hospital Violence Intervention Program.

Interventions

Brief Negotiation Interview intervention (BNI) (adapted) BEHAVIORAL

A brief motivational interview designed to increase motivation to reduce alcohol and/or cannabis use and engagement in treatment referral.

Brief Negotiation Interview intervention (BNI) (adapted)

Eligibility Criteria

• Age: 18 Years - 25 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Aim 1:
• Be clients of the Yale Hospital Violence Intervention Program (YHVIP)
• Be between the ages of 18-25 y/o upon study enrollment
• Have sustained an intentional injury inflicted by another person not considered to be a boy/girlfriend, fiancée, or spouse in the past year
• Report current alcohol and/or cannabis misuse
• Be English-speaking and able to provide informed consent.
• Aim 2 and 3:
• Present to Yale New Haven Hospital ED for an intentional injury inflicted by another person not considered to be a boy/girlfriend, fiancée, or spouse
• Be between the ages of 18-25 y/o upon study enrollment
• Report current alcohol and/or cannabis misuse
• Be English-speaking and able to provide informed consent.

You may not qualify if:

• Aim 1:
• Be actively suicidal or severely cognitively impaired precluding informed consent
• Sustain an intentional injury from a boy/girlfriend, fiancée, or spouse or sexual assault
• Be incarcerated or in police custody
• Currently engaged in addiction treatment
• Aim 2 and 3:
• Be actively suicidal or severely cognitively impaired precluding informed consent
• Sustain intentional injury from a boy/girlfriend, fiancée, spouse or by sexual assault
• Be incarcerated or in police custody
• Currently engaged in addiction treatment

Sponsors & Collaborators

• Yale University: lead
• National Institute on Drug Abuse (NIDA): collaborator

Study Sites (1)

Yale Department of Emergency Medicine

New Haven, Connecticut, 06520, United States

Location

MeSH Terms

Interventions

Acclimatization

Intervention Hierarchy (Ancestors)

Adaptation, Physiological; Physiological Phenomena; Adaptation, Biological; Biological Phenomena

Study Officials

• Edouard Coupet, MD, MS

  Yale University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Edouard Coupet Jr., MD, MS

CONTACT

(203) 584-9445; edouard.coupet@yale.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 8, 2025
• First Posted: July 17, 2025
• Study Start (Estimated): August 1, 2026
• Primary Completion (Estimated): February 1, 2028
• Study Completion (Estimated): February 1, 2028
• Last Updated: November 3, 2025

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will share

Locations

US (1)