Investigation of the Effects of Prehabilitation Education Delivered Through a Mobile Compatible Website on Quality of Life and Symptoms in Patients Undergoing Hematopoietic Stem Cell Transplantation

NCT07066592 | Active Not Recruiting DMC

• 1 other identifier: 2024-11/74
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

Aim of the Study: The aim of this study is to examine the effect of prehabilitation education delivered via a mobile-compatible website on the quality of life and symptom evaluation of patients undergoing hematopoietic stem cell transplantation (HSCT). Research Questions: What is the effect of prehabilitation education delivered via a mobile-compatible website on the quality of life of stem cell transplant patients? What is the effect of prehabilitation education delivered via a mobile-compatible website on the symptom management of stem cell transplant patients? Method: In this study, patients will be randomly assigned to one of two groups: One group will receive prehabilitation education through a mobile-compatible website. The other group will receive standard educational procedures.

Conditions

Hematological Malignancy; Prehabilitation; Patient Education

Keywords

prehabilitation; quality of life; bone marrow transplantation; education

Outcome Measures

Primary Outcomes (2)

• symptom management

  Edmonton Symptom Assessment Scale. Each symptom is evaluated using numerical ratings ranging from 0 to 10. A score of 0 indicates that the symptom is absent, while a score of 10 indicates that the symptom is felt very severely. The severity of the symptom increases progressively from 0 to 10. (The changes will be evaluated from the baseline level to the day of transplantation and up to the day of discharge. This period takes approximately 3-4 weeks on average)

  The baseline and average 3-4 weeks

• quality of functionality

  Functional Assessment of Cancer Therapy-Bone Marrow Transplant (4th version) The minimum score obtainable from the FACT-BMT scale is 0, and the maximum score is 148. Higher scores indicate a better quality of life. (The changes will be evaluated from the baseline level to the day of transplantation and up to the day of discharge. This period takes approximately 3-4 weeks on average)

  The baseline and average 3-4 weeks

Study Arms (2)

Prehabilitation education provided via mobile compatible website

EXPERIMENTAL

Participants will receive access to the educational website containing information on the stem cell transplantation process, consisting of 9 sections, one week prior to hospital admission.

Behavioral: Prehabilitation education provided via mobile compatible website

Control

NO INTERVENTION

Participants will receive routine care.

Interventions

Prehabilitation education provided via mobile compatible website BEHAVIORAL

The prehabilitation education delivered through a mobile-compatible website was developed specifically for patients who are candidates for stem cell transplantation. Through this platform, patients can easily and quickly access accurate information on managing potential symptoms during the transplant process, as well as guidance on nutrition and exercise aimed at improving their quality of life.

Prehabilitation education provided via mobile compatible website

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Undergoing Hematopoietic Stem Cell Transplantation (HSCT) for the first time
• Having no musculoskeletal problems that would prevent physical activity
• Volunteering to participate in the study
• Between 18 and 70 years of age
• Having access to and the ability to use a mobile phone and the internet
• Literate in Turkish (able to read and write in Turkish)

You may not qualify if:

• Having a condition that prevents effective communication
• Being illiterate (unable to read and write)
• Inability to use technology

Sponsors & Collaborators

• Saglik Bilimleri Universitesi: lead
• Ankara Oncology Research and Training Hospital: collaborator

Study Sites (1)

Ankara Oncology Training and Research Hospital

Ankara, Turkey (Türkiye)

Location

Related Publications (3)

• Normann AJ, Mo CC, Wilson RL, Perez M, Cutler C, Uno H, Thompson LV, Skinner TL, Richardson PG, Marinac CR, Dieli-Conwright CM. Prehabilitation Exercise Training to Target Improved Muscle Strength in Pretransplant Patients Diagnosed With Multiple Myeloma: Protocol for a Pilot Randomized Controlled Trial. JMIR Res Protoc. 2024 Dec 19;13:e64905. doi: 10.2196/64905.

  PMID: 39701583 BACKGROUND

• Naumann K, Singh B, Bushaway S, Crane R, Deepak S, Hartland A, Konstantopoulos P, Mansell E, Marinelli V, Pallotta V, Tolfts A, Virieux A, Wall M, Wilksch S, Zhuang M, Atkinson M, Maher C. Investigating the impact of multidisciplinary prehabilitation on deconditioning in patients eligible for haematopoietic allogenic stem cell transplantation: protocol for a feasibility trial. BMJ Open. 2024 Sep 5;14(9):e084372. doi: 10.1136/bmjopen-2024-084372.

  PMID: 39237275 BACKGROUND

• Dennett AM, Porter J, Ting SB, Taylor NF. Prehabilitation to improve function after autologous stem cell transplantation: A pilot randomized controlled trial (PIRATE). Support Care Cancer. 2025 Feb 7;33(3):164. doi: 10.1007/s00520-025-09179-1.

  PMID: 39920425 BACKGROUND

MeSH Terms

Conditions

Hematologic Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Hematologic Diseases; Hemic and Lymphatic Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 25, 2025
• First Posted: July 15, 2025
• Study Start: December 13, 2024
• Primary Completion: July 31, 2025
• Study Completion: August 15, 2025
• Last Updated: July 15, 2025

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)