Quantification & Classification of Inflammatory Cells in Uveitis Using OCT

NCT07065747 | Recruiting

• 2 other identifiers: OHSU IRB0008052R21EY036563
• Study Type: observational
• Target: 125
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to determine if it's possible to use a high resolution imaging device called optical coherence tomography (OCT) to develop an unbiased, standard method of counting and categorizing the various types of cells and proteins found in an eye condition called anterior uveitis. Anterior uveitis is a type of inflammation in the eye that can be caused by many different diseases of the body.

Conditions

Anterior Uveitis (AU); Birdshot Chorioretinitis; Behcet Disease; Herpes Simplex Virus; Juvenile Idiopathic Arthritis (JIA); Spondyloarthritis (SA); Sarcoidosis; Posterior Vitreous Detachment

Outcome Measures

Primary Outcomes (1)

• Identification & Measurement of Anterior Chamber Cells

  Anterior Chamber (AC) cells will be identified from OCT images by computer algorithms. AC cell number counted by OCT will be correlated with slit lamp grading. Cell size \& other characteristics identified from OCT images will be associated with different uveitis diagnostic categories. The Standardization of Uveitis Nomenclature (SUN) grading system (scale: 0 = none to 4+ = severe) will be used to compare OCT-derived quantification against slit-lamp grading performed by attending physicians.

  Day 1

Secondary Outcomes (4)

• Measure of AC Flare

  Day 1

• Measure of Keratic Precipitates

  Day 1

• Measure of Vitreous Cells

  Day 1

• Measurement of Vitreous Haze

  Day 1

Study Arms (3)

Uveitis Group

Eyes with active inflammation due to various systemic diseases

Posterior Vitreous Detachment Group

Eyes with vitreous floaters and posterior vitreous detachment

Healthy/Control Group

Healthy eyes with no history of uveitis, posterior vitreous detachment, or previous eye surgery

Eligibility Criteria

• Age: 5 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Study participants will be recruited from clinical practices of the investigators at Casey Eye Institute of Oregon Health \& Science University in Portland, Oregon.

You may qualify if:

• Uveitis Group: Eyes with active intraocular inflammation and a clinical diagnose of spondyloarthritis/HLA-B27 associated anterior uveitis, Juvenile Idiopathic Arthritis (JIA) associated chronic anterior uveitis, Herpes Simplex Virus (HSV) anterior uveitis, Birdshot chorioretinitis, Behcet disease uveitis, sarcoidosis associated uveitis, uveitis of any additional type, or uveitis masquerade.
• Posterior Vitreous Detachment Group: Eyes with vitreous floaters and posterior vitreous detachment (PVD).
• Healthy/Control Group: Healthy eyes with no history of uveitis, PVD, or previous eye surgery.

You may not qualify if:

• Inability to give informed consent.
• Inability to maintain stable fixation for OCT imaging.
• Inability to commit to required visits to complete the study.
• Pregnancy and breastfeeding.

Sponsors & Collaborators

• Oregon Health and Science University: lead
• National Eye Institute (NEI): collaborator

Study Sites (1)

Casey Eye Institute - Oregon Health & Science University

Portland, Oregon, 97239, United States

RECRUITING

MeSH Terms

Conditions

Uveitis, Anterior; Birdshot Chorioretinopathy; Behcet Syndrome; Herpes Simplex; Arthritis, Juvenile; Spondylarthritis; Sarcoidosis; Vitreous Detachment

Condition Hierarchy (Ancestors)

Panuveitis; Uveitis; Uveal Diseases; Eye Diseases; Chorioretinitis; Retinitis; Retinal Diseases; Choroiditis; Choroid Diseases; Uveitis, Posterior; White Dot Syndromes; Autoimmune Diseases; Immune System Diseases; Mouth Diseases; Stomatognathic Diseases; Vasculitis; Vascular Diseases; Cardiovascular Diseases; Hereditary Autoinflammatory Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin Diseases, Genetic; Skin Diseases; Skin and Connective Tissue Diseases; Skin Diseases, Vascular; Herpesviridae Infections; DNA Virus Infections; Virus Diseases; Infections; Skin Diseases, Viral; Skin Diseases, Infectious; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Spondylitis; Spinal Diseases; Bone Diseases; Lymphoproliferative Disorders; Lymphatic Diseases; Hemic and Lymphatic Diseases; Hypersensitivity, Delayed; Hypersensitivity

Study Officials

• Yan Li, PhD

  Oregon Health and Science University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Humberto Martinez, COT, MBA

CONTACT

503-494-7712; martinhu@ohsu.edu

Denzil Romfh, OD

CONTACT

503-494-4351; romfhd@ohsu.edu

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: July 2, 2025
• First Posted: July 15, 2025
• Study Start: September 1, 2024
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: July 17, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)