VR-based Multi-dimensional Intervention on Cognitive Function, With AI-agents

NCT07064382 | Not Yet Recruiting

• 1 other identifier: MiM20250101
• Study Type: interventional
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

Virtual Reality-based multi-dimensional intervention for cognition and well-being will be provided to older adults, with AI-agents. The digital health intervention include physical activity, gamification, cognitive trainings. Cognition, like memory, spatial function, sleepiness and mental health will be studied as outcomes.

Conditions

Dementia; Sleepiness; Mental Health; Alzheimer Disease

Outcome Measures

Primary Outcomes (5)

• Spatial cognition

  mental rotation task,higher score means stronger spatial ability

  pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year

• Spatial cognition

  money road map test, higher score means stronger spatial ability

  pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year

• Spatial cognition

  building memory test, higher score means stronger spatial ability

  pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year

• Spatial cognition

  corsi, , higher score means stronger spatial ability

  pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year

• Spatial cognition

  digit span, higher score means stronger spatial ability

  pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year

Secondary Outcomes (3)

• mental health

  pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year

• mental health

  pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year

• mental health

  pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year

Other Outcomes (1)

• Sleepiness

  pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year

Study Arms (2)

control

NO INTERVENTION

usual care

VR-based intervention

EXPERIMENTAL

Provide VR-based multi-dimensional intervention

Device: VR-based multi-dimensional intervention

Interventions

VR-based multi-dimensional intervention DEVICE

VR-based multi-dimensional intervention, including LLMs, AI-agents

VR-based intervention

Eligibility Criteria

• Age: 60 Years - 120 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• older adults

You may not qualify if:

• cannot attend physical activity like pedalling rehabilitation bike
• other health issues (assessed by health professionals)

Sponsors & Collaborators

• Hong Kong University of Science and Technology: lead

MeSH Terms

Conditions

Dementia; Sleepiness; Psychological Well-Being; Alzheimer Disease

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Personal Satisfaction; Behavior; Tauopathies; Neurodegenerative Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: two groups, one is control (usual care), one is VR-based multi-dimensional intervention, including LLMs, AI-agent

Study Record Dates

• First Submitted: June 14, 2025
• First Posted: July 14, 2025
• Study Start: July 15, 2025
• Primary Completion (Estimated): June 15, 2028
• Study Completion (Estimated): June 15, 2028
• Last Updated: July 14, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share