Feasibility, Accuracy, and Reproducibility of Virtual Reality Visual Field Testing in Patients With Glaucoma

NCT07063537 | Recruiting

• 1 other identifier: 1030608
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to evaluate the feasibility of using virtual reality based visual field testing to monitor glaucoma in a clinical setting. This will be done through comparison of a virtual reality (VR) based device to the current gold standard Ziess Humphrey Field Analyzer (HFA). The main questions the study aims to answer are:

• Can both devices produce similar results in terms of detecting visual field defects and progression?
• Does the stage (early, moderate, advanced) of glaucoma impact results between the two devices? Participants will perform both a standard and a VR based visual field test at each visit, for a total of 5 visits.

Conditions

Glaucoma Open-Angle

Keywords

Virtual Reality; Visual Field; Glaucoma

Outcome Measures

Primary Outcomes (3)

• Visual field point-wise threshold values

  Both the VR visual field and HFA produce threshold light sensitivity values measured in decibels (db) at the same locations in space (e.g., 24-2 protocol with stimuli 6 degrees apart at locations up to 30 degrees from central fixation)

  Measured during each visual field test on visits 1 through 5 (throughout study completion, average 2 months)

• Global indices of visual field loss

  Mean deviation (MD) and pattern standard deviation (PSD) are measurements of global field loss produced by both devices.

  Measured during each visual field test on visits 1 through 5 (throughout study completion, average 2 months)

• Reliability Indices

  Fixation losses, false positives, false negatives are recorded during each visual field test and reflect the reliability of the given test.

  Measured during each visual field test on visits 1 through 5 (throughout study completion, average 2 months)

Secondary Outcomes (2)

• Reliability over time

  Measured during each visual field test on visits 1 through 5 (throughout study completion, average 2 months)

• Patient satisfaction

  Questionnaire completed at the end of each testing session, following the completion of both visual field tests (throughout study enrolment, average 2 months)

Study Arms (1)

Visual Field Testing

EXPERIMENTAL

Participants will perform both a virtual reality-based visual field test and a standard Humphrey visual field test for both eyes.

Device: Virtual Reality Visual Field (VR-VF)

Interventions

Virtual Reality Visual Field (VR-VF) DEVICE

Both devices administer a standard visual field test. The Humphrey is the gold standard desk top model and the VR-VF is a virtual reality headset designed to deliver visual field testing

Visual Field Testing

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \>18 years of age
• diagnosis of primary open-angle glaucoma
• ability to perform visual field testing
• capacity to provide informed consent to research protocol

You may not qualify if:

• diagnosis of secondary glaucoma or non-glaucomatous optic neuropathy
• previous intraocular surgery (excluding cataract surgery and minimally invasive glaucoma surgery)
• significant media opacity
• pregnancy
• seizure disorder
• cardiac pacemaker/other implantable device
• severe vertigo/balance disorder

Sponsors & Collaborators

• Nova Scotia Health Authority: lead

Study Sites (1)

Eadie Technologies Inc

Halifax, Nova Scotia, B3L1N3, Canada

RECRUITING

Related Publications (4)

• Canadian Ophthalmological Society Glaucoma Clinical Practice Guideline Expert Committee; Canadian Ophthalmological Society. Canadian Ophthalmological Society evidence-based clinical practice guidelines for the management of glaucoma in the adult eye. Can J Ophthalmol. 2009;44 Suppl 1:S7-93. doi: 10.3129/cjo44s1. No abstract available. English, French.

  PMID: 19492005 BACKGROUND

• Selvan K, Mina M, Abdelmeguid H, Gulsha M, Vincent A, Sarhan A. Virtual reality headsets for perimetry testing: a systematic review. Eye (Lond). 2024 Apr;38(6):1041-1064. doi: 10.1038/s41433-023-02843-y. Epub 2023 Nov 30.

  PMID: 38036608 BACKGROUND

• Glen FC, Baker H, Crabb DP. A qualitative investigation into patients' views on visual field testing for glaucoma monitoring. BMJ Open. 2014 Jan 10;4(1):e003996. doi: 10.1136/bmjopen-2013-003996.

  PMID: 24413347 BACKGROUND

• Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology. 2014 Nov;121(11):2081-90. doi: 10.1016/j.ophtha.2014.05.013. Epub 2014 Jun 26.

  PMID: 24974815 BACKGROUND

MeSH Terms

Conditions

Glaucoma, Open-Angle; Glaucoma

Condition Hierarchy (Ancestors)

Ocular Hypertension; Eye Diseases

Study Officials

• Brennan Eadie, MD, PhD, FRCSC

  Nova Scotia Health

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Reann Post, BSc

CONTACT

19029560601; reann.post@dal.ca

Lynn Murphy

CONTACT

19024072380; lynn@eadietech.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD, FRCSC. Assistant Professor, Glaucoma Division; Department of Ophthalmology and Visual Sciences. Dalhousie University

Model Details: All participants will perform both a Humphrey visual field test and a virtual reality based visual field test.

Study Record Dates

• First Submitted: June 20, 2025
• First Posted: July 14, 2025
• Study Start: December 14, 2024
• Primary Completion: October 1, 2025
• Study Completion: October 1, 2025
• Last Updated: July 14, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)