TTE Improves Clinical Management of Stable Chest Pain

NCT07063147 | Recruiting

• 1 other identifier: 2025KY-019-01
• Study Type: observational
• Target: 50,000
• Locations: 1 country
• Sites: 1

Brief Summary

The investigator aims to prospectively enroll patients who were referred for transthorcic echocardiography (TTE) for the assessment of stable chest pain (SCP) suspected of obstructive coronary artery disease (CAD). All patients underwent TTE according to established guidelines and local institutional protocols. This study will determine if TTE-based imaging evaluation can provide more informaton to improve clinical management for SCP, including fewer MACE and better decision-making of downstream investigations and therapeutic interventions.

Conditions

Transthorcic Echocardiography; Stable Angina Pectoris; Coronary Artery Disease; Major Adverse Cardiac Events; Invasive Coronary Angiography

Outcome Measures

Primary Outcomes (1)

• Major adverse cardiovascular events

  10 years

Secondary Outcomes (3)

• Invasive coronary angiography

  10 years

• Medication prescription

  10 years

• Coronary revascularization

  10 years

Study Arms (1)

TTE

Diagnostic Test: TTE

Interventions

TTE DIAGNOSTIC_TEST

All patients underwent TTE according to established guidelines and local institutional protocols. The imaging data were evaluated using different image post-processing software to comprehensively analyse anatomical, functional and histological information of coronary.

TTE

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who were referred for TTE for the assessment of SCP suspected of CAD.

You may qualify if:

• symptomatic patients with SCP suspected of obstructive CAD.
• referred for TTE for the assessment of SCP.
• ≥18 years of age.
• signed informed consent.

You may not qualify if:

• acute coronary syndromes
• previous CAD or coronary revascularization
• nonsinus rhythm
• cardiomyopathy, valvular disease, congenital heart disease or left cardiac insufficiency because of other reasons

Sponsors & Collaborators

• Tianjin Chest Hospital: lead

Study Sites (1)

Tianjin Chest Hospital

Tianjin, China

RECRUITING

MeSH Terms

Conditions

Angina, Stable; Coronary Artery Disease; Cardiovascular Diseases

Condition Hierarchy (Ancestors)

Angina Pectoris; Myocardial Ischemia; Heart Diseases; Vascular Diseases; Chest Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Coronary Disease; Arteriosclerosis; Arterial Occlusive Diseases

Central Study Contacts

Jia Zhou

CONTACT

+8615522485560; zhoujiawenzhang@126.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 10 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 3, 2025
• First Posted: July 14, 2025
• Study Start: January 1, 2025
• Primary Completion (Estimated): December 31, 2030
• Study Completion (Estimated): December 31, 2040
• Last Updated: July 18, 2025

Record last verified: 2025-07

Locations

CN (1)